[CAS NO. 2417988-00-0] JB062

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PRODUCTS SPECIFICATIONS [2417988-00-0]

Catalog

HY-152206

Brand

MCE

CAS

2417988-00-0

DESCRIPTION [2417988-00-0]

Overview

MDL	-
Molecular Weight	323.34
Molecular Formula	C19H17NO4
SMILES	OC(C1=CC=CC=C1O2)=C(/C(C)=N/CC3=CC=C(OC)C=C3)C2=O

For research use only. We do not sell to patients.

Summary

JB062 is a nonmuscle myosin inhibitor with IC ₅₀ values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin , Cardiac muscle myosin , and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy ^[1] .

IC50 & Target

IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II) ^[1]

In Vitro

JB062 (compound 6b; 40 μM; 24 h) inhibits cytokinesis in Cos-7 cells ^[1] .
JB062 (COS-7 cells) has cytotoxic to human cancer cells but not normal cells with a CC ₁₀ value of 36 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.