[CAS NO. 2437-29-8] Malachite green hemioxalate

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PRODUCTS SPECIFICATIONS [2437-29-8]

Catalog

HY-D0162

Brand

MCE

CAS

2437-29-8

DESCRIPTION [2437-29-8]

Overview

MDL	MFCD00011766
Molecular Weight	463.50
Molecular Formula	C23H25N2.1/2C2H2O4.C2HO4
SMILES	C/[N+](C)=C1C=C/C(C=C/1)=C(C2=CC=C(N(C)C)C=C2)\C3=CC=CC=C3.O=C(O)C([O-])=O.O=C(O)C(O)=O.[1/2]

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Mol Ther Oncolytics. 25 August 2022.

Summary

Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE , and inhibits its downstream targets such as IκBα , p65 and IRF3 . Malachite green oxalate exhibits antitumor activity in vitro and in vivo ^[1] ^[2] ^[3] .

IC50 & Target

IKBKE ^[3]

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 10 mg/mL ( 21.57 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1575 mL	10.7875 mL	21.5750 mL
5 mM	0.4315 mL	2.1575 mL	4.3150 mL
10 mM	0.2157 mL	1.0787 mL	2.1575 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Methanaminium, N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methyl-, ethanedioate, ethanedioate (2:2:1)

Malachite green oxalate

Ammonium, [4-[p-(dimethylamino)-α-phenylbenzylidene]-2,5-cyclohexadien-1-ylidene]dimethyl-, oxalate (1:1), oxalate (1:1)

Ethanedioic acid, ion(1-), N-[4-[[4-(dimethylamino)phenyl]phenylmethylene]-2,5-cyclohexadien-1-ylidene]-N-methylmethanaminium, ethanedioate (2:1)

Malachite green oxalate salt

C. I. Basic Green