[CAS NO. 2438637-61-5] NRX-252262

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PRODUCTS SPECIFICATIONS [2438637-61-5]

Catalog

HY-111760

Brand

MCE

CAS

2438637-61-5

DESCRIPTION [2438637-61-5]

Overview

MDL	MFCD32062681
Molecular Weight	545.36
Molecular Formula	C23H17Cl2F3N2O4S
SMILES	O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1

For research use only. We do not sell to patients.

Summary

NRX-252262 is a potent enhancer of the interaction between β-Catenin , and its cognate E3 ligase , SCF ^β-TrCP , induces mutant β-catenin degradation, with an EC ₅₀ of 3.8 nM ^[1] .

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCF ^β-TrCP ) ^[1]

In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL ( 15.27 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8337 mL	9.1683 mL	18.3365 mL
5 mM	0.3667 mL	1.8337 mL	3.6673 mL
10 mM	0.1834 mL	0.9168 mL	1.8337 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.