[CAS NO. 2445205-24-1] CDK4/6-IN-12
PRODUCTS SPECIFICATIONS [2445205-24-1]
DESCRIPTION [2445205-24-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 238.25 |
| Molecular Formula | C12H10N6 |
| SMILES | CC1=CN2C3=NC(N)=NC=C3C(C)=C(C2=N1)C#N |
Summary
CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity for CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used for the research of cancer [1] .
IC50 & Target
|
CDK4 592.3 nM (IC 50 ) |
CDK6 3090 nM (IC 50 ) |
In Vitro
CDK4/6-IN-12 (compound 4a) inhibits CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.