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[CAS NO. 2451481-08-4] Sulfopin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-139361 |
| Brand: | MCE |
| CAS: | 2451481-08-4 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 281.80 |
| Molecular Formula | C11H20ClNO3S |
| SMILES | O=C(N(CC(C)(C)C)C(CC1)CS1(=O)=O)CCl |
1 Publications Citing Use of MCE
Summary
In Vitro
MDA-MB-468 cells show the most pronounced sensitivity to Sulfopin (1, 2.5 μM; 4-8 days)
[1]
.
Sulfopin (2 μM, HEK293 cells; 48 hours) downregulates Myc transcription
[1]
.
Sulfopin (1, 2.5 μM; PATU-8988T cells; 4 days) shows a small but significant reduction in the number of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Kuramochi, MDA-MB-468, NGP, NBL-S, MDA-MB-468 cells |
| Concentration: | 1, 2.5 μM |
| Incubation Time: | 4,6, 8 days |
| Result: | Showed variation in antiproliferative effects across cancer cell lines Kuramochi, MDA-MB-468, NGP and NBL-S, with the most pronounced sensitivity observed in MDA-MB-468 cells. |
In Vivo
Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice
[1]
.
Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice
[1]
.
Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Transgenic Th-MYCN mice [1] |
| Dosage: | 40 mg/kg |
| Administration: | Once a day (QD) or twice a day (BID) for 7 days |
| Result: | Sulfopin-treated QD mice showed a significant average increase in survival of 10 days, while Sulfopin-treated BID mice showed an even more pronounced average increase of 28 days. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 354.86 mM ; Need ultrasonic)
H 2 O : 4.35 mg/mL ( 15.44 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5486 mL | 17.7431 mL | 35.4862 mL |
| 5 mM | 0.7097 mL | 3.5486 mL | 7.0972 mL |
| 10 mM | 0.3549 mL | 1.7743 mL | 3.5486 mL |
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