[CAS NO. 2457317-40-5] CDK8-IN-10
PRODUCTS SPECIFICATIONS [2457317-40-5]
DESCRIPTION [2457317-40-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 525.87 |
| Molecular Formula | C25H15ClF3N5O3 |
| SMILES | O=C(NC1=CC=C(N2C3=CC=NC=C3)C(OC4=NC=CC=C4C2=O)=C1)NC5=CC=C(Cl)C(C(F)(F)F)=C5 |
Summary
CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC 50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer [1] .
IC50 & Target
|
CDK8 8.25 nM (IC 50 ) |
In Vitro
CDK8-IN-10 (compound 2; 8 h; SW620 cells) reduces phosphorylation of CDK8 substrate STAT1 in cells with an IC 50 value of 1.3 µM [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.