[CAS NO. 2470908-79-1] YS-370
PRODUCTS SPECIFICATIONS [2470908-79-1]
DESCRIPTION [2470908-79-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 663.60 |
| Molecular Formula | C37H35BrN4O3 |
| SMILES | COC1=CC2=NC=NC(C3=C(C4=CC=CC=C4)N(CC5=CC=CC=C5Br)C6=C3C=CC=C6)=C2C=C1OCCCN7CCOCC7 |
Summary
YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein ( P-gp ). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity [1] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 8.33 mg/mL ( 12.55 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.5069 mL | 7.5347 mL | 15.0693 mL |
| 5 mM | 0.3014 mL | 1.5069 mL | 3.0139 mL |
| 10 mM | 0.1507 mL | 0.7535 mL | 1.5069 mL |