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[CAS NO. 2479465-67-1] EBOV/MARV-IN-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-137498 |
| Brand: | MCE |
| CAS: | 2479465-67-1 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 461.52 |
| Molecular Formula | C25H30F3N3O2 |
| SMILES | O=C(NC1=CC=C(N2CCC(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(CN4CCOCC4)C=C3 |
Summary
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) , with broad-spectrum activity ( EC 50 =0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells [1] .
IC50 & Target
EC50: 0.31 µM (EBOV), 0.82 µM (MARV) [1]
In Vitro
EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC 50 =12 nM) and HIV/MARV-GP (EC 50 =180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088) [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 216.68 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1668 mL | 10.8338 mL | 21.6675 mL |
| 5 mM | 0.4334 mL | 2.1668 mL | 4.3335 mL |
| 10 mM | 0.2167 mL | 1.0834 mL | 2.1668 mL |
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