[CAS NO. 2479465-67-1] EBOV/MARV-IN-1

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PRODUCTS SPECIFICATIONS [2479465-67-1]

Catalog

HY-137498

Brand

MCE

CAS

2479465-67-1

DESCRIPTION [2479465-67-1]

Overview

MDL	-
Molecular Weight	461.52
Molecular Formula	C25H30F3N3O2
SMILES	O=C(NC1=CC=C(N2CCC(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(CN4CCOCC4)C=C3

For research use only. We do not sell to patients.

Summary

EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) , with broad-spectrum activity ( EC ₅₀ =0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells ^[1] .

IC50 & Target

EC50: 0.31 µM (EBOV), 0.82 µM (MARV) ^[1]

In Vitro

EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC ₅₀ =12 nM) and HIV/MARV-GP (EC ₅₀ =180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 216.68 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1668 mL	10.8338 mL	21.6675 mL
5 mM	0.4334 mL	2.1668 mL	4.3335 mL
10 mM	0.2167 mL	1.0834 mL	2.1668 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.42 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225.