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[CAS NO. 2485005-22-7] GPX4-IN-2
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-138556 |
| Brand: | MCE |
| CAS: | 2485005-22-7 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 444.65 |
| Molecular Formula | C30H40N2O |
| SMILES | CCCC[C@@H]1N[C@H](C(C(C1)=C2)=CC=C2OC)C3=CC=C(C=C3)NC4(C[C@H](C5)C6)C[C@H]6C[C@H]5C4 |
Summary
IC50 & Target
GPX4 [1]
In Vitro
GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) shows antiproliferative activity with IC 50 s of 0.004, 0.016, 2.9 µM for 786-O, SJSA-1, A431 cells, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | SJSA-1, 786-O, A431 cells |
| Concentration: | 0.0005-10 mM |
| Incubation Time: | 24 h |
| Result: | Inhibited cell proliferation with IC 50 s of 0.004, 0.016, 2.9 µM for 786-O, SJSA-1, A431 cells, respectively. |
In Vivo
GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) shows a good pharmacokinetics profile in mice and rats [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | 6-8 weeks, 22-25 g, Male Balb/c mice, 6-8 weeks, 200-250 g, male SD rats [1] |
| Dosage: | 5 mg/kg for mouse, 2 mg/kg for rats |
| Administration: | I.v. |
| Result: | Showed a good pharmacokinetics with T 1/2 of 3.5 h, C max of 5446 ng/mL, AUC of 1635 ng·h/mL, CL of 49 mL/min/kg, Vd of 14.7 L/kg in mice, T 1/2 of 3.15 h, C max of 3529 ng/mL, AUC of 1082 ng·h/mL, CL of 30 mL/min/kg, Vd of 8.2 L/kg in rats. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
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