[CAS NO. 2485135-31-5] Topoisomerase I inhibitor 4

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [2485135-31-5]

Catalog

HY-143301

Brand

MCE

CAS

2485135-31-5

DESCRIPTION [2485135-31-5]

Overview

MDL	-
Molecular Weight	386.42
Molecular Formula	C23H19FN4O
SMILES	O=C1C2=C(N=C3C4=CC5=CC=CC=C5C=C4CN13)C=C(C(F)=C2)N6CCNCC6

For research use only. We do not sell to patients.

Summary

Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC ₅₀ s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer ^[1] .

IC50 & Target

IC50: 1.20 μM (HepG2), 2.09 μM (A549), 1.56 μM (MCF-7), 1.92 μM (HeLa) ^[1]

In Vitro

Topoisomerase I inhibitor 4 (1-80 μM) shows Top1 inhibitory activity ^[1] .
Topoisomerase I inhibitor 4 (0-40 μM; 48 h) inhibits proliferation of cancer cells ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay ^[1]

Cell Line:	HepG2, A549, MCF-7 and HeLa cell lines
Concentration:	0-40 μM
Incubation Time:	48 hours
Result:	Showed antiproliferative activities to HepG2, A549, MCF-7 and HeLa cells with IC ₅₀ s of 1.20, 2.09, 1.56 and 1.92 μM, respectively.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021).