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[CAS NO. 255730-18-8] Artemisone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-19502 |
| Brand: | MCE |
| CAS: | 255730-18-8 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 401.52 |
| Molecular Formula | C19H31NO6S |
| SMILES | C[C@H]1[C@H](N2CCS(CC2)(=O)=O)O[C@@]3([H])[C@]45[C@@]([C@H](C)CC[C@]51[H])([H])CC[C@@](O3)(C)OO4 |
1 Publications Citing Use of MCE
Summary
IC50 & Target
|
Plasmodium
|
In Vitro
Artemisone inhibits 3D7 and K1 P. falciparum , with IC 50 s of 0.88±0.59 and 1.23±0.64 nM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Artemisone is effectve at inhibiting the parasitaemia in the
P. berghei
NY susceptible strain, with an ED
50
of 9.62 mg/kg via subcutaneous route and 11.67 mg/kg via oral administration
[1]
.
Artemisone (3, 1, 0.3 and 0.1 mg/kg, s.c.) in combination with ohter antimalarials has enhanced effect against the chloroquine-resistant line
P. yoelii
NS
[1]
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 130 mg/mL ( 323.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.4905 mL | 12.4527 mL | 24.9054 mL |
| 5 mM | 0.4981 mL | 2.4905 mL | 4.9811 mL |
| 10 mM | 0.2491 mL | 1.2453 mL | 2.4905 mL |
References
Synonyms
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