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[CAS NO. 2566-34-9] MeAIB
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-134452 |
| Brand: | MCE |
| CAS: | 2566-34-9 |
Overview
| MDL | MFCD00004191 |
|---|---|
| Molecular Weight | 117.15 |
| Molecular Formula | C5H11NO2 |
| SMILES | CC(C)(NC)C(O)=O |
1 Publications Citing Use of MCE
Summary
MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1) . ATA mediate the uptake of short-chain neutral amino acids in a Na + -dependent manner [1] .
In Vitro
ATA3 is a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. ATA1 (also known as GlnT) and ATA2 (also known as SAT2), have been cloned from rat and human tissues. These transporters mediate the uptake of short-chain neutral amino acids in a Na + -dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02232672 | Odense University Hospital |
Prostate Cancer
|
November 2016 | Not Applicable |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
H 2 O : 100 mg/mL ( 853.61 mM ; Need ultrasonic)
DMSO : 50 mg/mL ( 426.80 mM ; ultrasonic and warming and adjust pH to 2 with 1M HCl and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 8.5361 mL | 42.6803 mL | 85.3606 mL |
| 5 mM | 1.7072 mL | 8.5361 mL | 17.0721 mL |
| 10 mM | 0.8536 mL | 4.2680 mL | 8.5361 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (853.61 mM); Clear solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (21.34 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (21.34 mM); Clear solution
References
- [1] M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13.
- [2] Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41.
Synonyms
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