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[CAS NO. 25775-90-0] (Z)-Capsaicin
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1583 |
| Brand: | MCE |
| CAS: | 25775-90-0 |
Overview
| MDL | MFCD00209942 |
|---|---|
| Molecular Weight | 305.41 |
| Molecular Formula | C18H27NO3 |
| SMILES | CC(C)/C=C\CCCCC(NCC1=CC=C(O)C(OC)=C1)=O |
Summary
(Z)-Capsaicin is the cis isomer of capsaicin, acts as an orally active TRPV1 agonist, and is used in the research of neuropathic pain.
IC50 & Target
TRPV1 receptor [1]
In Vitro
(Z)-Capsaicin is the cis isomer of capsaicin, acting as a TRPV1 agonist. (Z)-Capsaicin may also blocks the neruonal calcium channel [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
(Z)-Capsaicin (Zucapsaicin) significantly attenuates nociceptive behavior after oral administration in rats. (Z)-Capsaicin is also tolerated in the primary or recurrent experimental genital herpes simplex virus infection in guinea pigs [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00995306 | Winston Laboratories |
Osteoarthritis of the Knee
|
June 2003 | Phase 3 |
| NCT00069082 | Winston Laboratories |
Episodic Cluster Headache
|
August 2003 | Phase 3 |
| NCT00758433 | Winston Laboratories |
Healthy Volunteers
|
September 2008 | Phase 1 |
| NCT00033839 | Winston Laboratories |
Episodic Cluster Headache
|
January 2002 | Phase 3 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 125 mg/mL ( 409.29 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2743 mL | 16.3714 mL | 32.7429 mL |
| 5 mM | 0.6549 mL | 3.2743 mL | 6.5486 mL |
| 10 mM | 0.3274 mL | 1.6371 mL | 3.2743 mL |
Synonyms
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