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[CAS NO. 2586-60-9] Direct Violet 1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-D1270 |
| Brand: | MCE |
| CAS: | 2586-60-9 |
Overview
| MDL | MFCD00046486 |
|---|---|
| Molecular Weight | 728.66 |
| Molecular Formula | C32H22N6Na2O8S2 |
| SMILES | O=S(C1=CC(O)=C2C(/N=N/C3=CC=C(C4=CC=C(/N=N/C5=C(N)C=CC6=CC(S(=O)(O[Na])=O)=CC(O)=C56)C=C4)C=C3)=C(N)C=CC2=C1)(O[Na])=O |
Summary
IC50 & Target
IC50: 1.47 µM (SARS-CoV-2-S-RBD binding to ACE2); 2.63 µM (SARS-CoV-S1S2 binding to ACE2); 2.11 µM (TNF-R1-TNFα binding) [1]
In Vitro
Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC
50
values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively
[1]
.
Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC
50
of 35.8 µM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 62.5 mg/mL ( 85.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.3724 mL | 6.8619 mL | 13.7238 mL |
| 5 mM | 0.2745 mL | 1.3724 mL | 2.7448 mL |
| 10 mM | 0.1372 mL | 0.6862 mL | 1.3724 mL |
References
- [1] Damir Bojadzic, et al. Small-Molecule In Vitro Inhibitors of the Coronavirus Spike-ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. bioRxiv, 2020 Oct 22.
- [2] Wafaa M Abd El-Rahim, et al. Genotoxicity studies on the removal of a direct textile dye by a fungal strain, in vivo, using micronucleus and RAPD-PCR techniques on male rats. J Appl Toxicol. 2008 May;28(4):484-90.
Synonyms
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