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[CAS NO. 25913-34-2] Tinoridine hydrochloride
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-111354 |
| Brand: | MCE |
| CAS: | 25913-34-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 352.88 |
| Molecular Formula | C17H21ClN2O2S |
| SMILES | O=C(C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2)OCC.Cl |
Summary
Tinoridine hydrochloride is a nonsteroidal anti-inflammatory drug and also has potent radical scavenger and antiperoxidative activity.
In Vitro
Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe 2+ , in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe 2+ , but its oxidation is slow in the absence of Fe 2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H 2 O 2 -Fe 2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl 4 -induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT01224756 | Takeda |
Pain|Inflammation
|
November 2010 | Phase 4 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 16.67 mg/mL ( 47.24 mM ; Need ultrasonic)
H 2 O : 2.5 mg/mL ( 7.08 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8338 mL | 14.1691 mL | 28.3382 mL |
| 5 mM | 0.5668 mL | 2.8338 mL | 5.6676 mL |
| 10 mM | 0.2834 mL | 1.4169 mL | 2.8338 mL |
-
1.
-
2.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1.67 mg/mL (4.73 mM); Clear solution
References
Synonyms
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