[CAS NO. 261365-11-1] MB05032
PRODUCTS SPECIFICATIONS [261365-11-1]
DESCRIPTION [261365-11-1]
Overview
| MDL | MFCD14584901 |
|---|---|
| Molecular Weight | 302.29 |
| Molecular Formula | C11H15N2O4PS |
| SMILES | CC(C)CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1 |
2 Publications Citing Use of MCE
Summary
MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC 50 value of 16 nM.
IC50 & Target
IC50: 16 nM (Human Liver FBPase) [1]
In Vivo
MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZDF rats with mild diabetes and aged ZDF rats with overt diabetes [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | ZDF rats (8- to 9-week-old (mild diabetes) and 12- to 13-week-old (overt diabetes)) [1] |
| Dosage: | 3, 6, 10, 30, 300 mg/kg (young ZDF rats); 6, 10, 30, 300 mg/kg (aged ZDF rats) |
| Administration: | Oral administration; once |
| Result: | Results in dose-dependent glucose lowering. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 165.40 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3081 mL | 16.5404 mL | 33.0808 mL |
| 5 mM | 0.6616 mL | 3.3081 mL | 6.6162 mL |
| 10 mM | 0.3308 mL | 1.6540 mL | 3.3081 mL |
References
- [1] Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.
- [2] Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151(10):4688-95.