[CAS NO. 261901-57-9] SB-269970hydrochloride

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PRODUCTS SPECIFICATIONS [261901-57-9]

Catalog

HY-15370A

Brand

MCE

CAS

261901-57-9

DESCRIPTION [261901-57-9]

Overview

MDL	MFCD03788020
Molecular Weight	388.95
Molecular Formula	C18H29ClN2O3S
SMILES	OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pK _i of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors ^[1] ^[2] .

IC50 & Target

5-HT ₇ Receptor

8.3 (pKi)

In Vivo

SB269970 hydrochloride (SB-269970A) (3-30 mg/kg; i.p.; once) significantly blocks amphetamine and ketamine-induced hyperactivity ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male C57BL6/J mice ^[1]
Dosage:	3, 10, 30 mg/kg
Administration:	Intraperitoneal injection; once
Result:	Significantly blocked amphetamine and ketamine-induced hyperactivity.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL ( 77.13 mM )

H ₂ O : 10 mg/mL ( 25.71 mM ; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5710 mL	12.8551 mL	25.7102 mL
5 mM	0.5142 mL	2.5710 mL	5.1420 mL
10 mM	0.2571 mL	1.2855 mL	2.5710 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: PBS

Solubility: 10 mg/mL (25.71 mM); Clear solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (6.43 mM); Clear solution

* All of the co-solvents are available by MCE.