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[CAS NO. 2632-13-5] PTP inhibitor 1

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Catalog:	HY-W013478
Brand:	MCE
CAS:	2632-13-5

Overview

MDL	MFCD00000201
Molecular Weight	229.07
Molecular Formula	C9H9BrO2
SMILES	COC1=CC=C(C(CBr)=O)C=C1

For research use only. We do not sell to patients.

Summary

PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor, with anti-angiogenic effect ^[1] .

IC50 & Target

PTP ^[1]

In Vitro

PTP inhibitor 1 exhibits anti-angiogenic activity with an IC ₅₀ of 3.7 μM for HUVECs ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 436.55 mM )

H ₂ O : 1 mg/mL ( 4.37 mM ; ultrasonic and warming and heat to 80°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3655 mL	21.8274 mL	43.6548 mL
5 mM	0.8731 mL	4.3655 mL	8.7310 mL
10 mM	0.4365 mL	2.1827 mL	4.3655 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (10.91 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Sylvest L, et al. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.

Synonyms

Ethanone, 2-bromo-1-(4-methoxyphenyl)-

Acetophenone, 2-bromo-4′-methoxy-

2-Bromo-1-(4-methoxyphenyl)ethanone

4-Methoxyphenacyl bromide

2-Bromo-4′-methoxyacetophenone

p-Methoxyphenacyl bromide

2-Bromo-p-methoxyacetophenone

4′-Methoxy-2-bromoacetophenone

ω-Bromo-4′-methoxyacetophenone

α-Bromo-p-methoxyacetophenone

4′-Methoxyphenacyl bromide

α-Bromo-4′-methoxyacetophenone

Bromomethyl p-anisyl ketone

2-Bromo-1-(4-methoxyphenyl)-1-ethanone

2-(4-Methoxyphenyl)-2-oxoethyl bromide

ω-Bromo-p-methoxyacetophenone

Bromomethyl p-methoxyphenyl ketone

α-Bromo-4-methoxyacetophenone

Bromomethyl 4-methoxyphenyl ketone

4-Methoxy-2′-bromoacetophenone

NSC 129010

2-Bromo-1-[4-(methyloxy)phenyl]ethanone

1-(Bromoacetyl)-4-methoxybenzene

p-Methoxy-2-bromoacetophenone

2-Bromo-(4-methoxyphenyl)ethan-1-one

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