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[CAS NO. 2671128-05-3] FHD-286
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-144835 |
| Brand: | MCE |
| CAS: | 2671128-05-3 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 562.66 |
| Molecular Formula | C24H30N6O6S2 |
| SMILES | COC[C@@H](C(NC1=NC(C2=CC=CC(N3C[C@@H](O[C@@H](C3)C)C)=N2)=CS1)=O)NC(C4=CN(C=C4)S(C)(=O)=O)=O |
Summary
FHD-286 is a BRG1/BRM ATPase inhibitor for the treatment of BAF-related disorders such as acute myeloid leukemia.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04891757 | Foghorn Therapeutics Inc. |
Advanced Hematologic Malignancy|Relapsed Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia|Relapsed Myelodysplastic Syndromes|Refractory Myelodysplastic Syndromes
|
June 14, 2021 | Phase 1 |
| NCT04879017 | Foghorn Therapeutics Inc. |
Metastatic Uveal Melanoma
|
May 17, 2021 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 250 mg/mL ( 444.32 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.7773 mL | 8.8864 mL | 17.7727 mL |
| 5 mM | 0.3555 mL | 1.7773 mL | 3.5545 mL |
| 10 mM | 0.1777 mL | 0.8886 mL | 1.7773 mL |
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