Your shopping cart is empty!
Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
Catalog: | HY-D1726 |
Brand: | MCE |
CAS: | 2705841-53-6 |
MDL | - |
---|---|
Molecular Weight | 688.60 |
Molecular Formula | C33H39BF2N10O2S |
SMILES | O=C(N1CC2=C(N=C(S2)NC([C@@H]3CN(CC3)C#N)=O)CC1)CN(N=N4)C=C4CCCCC(C5=C(C)C=C(C)[N-]5[B+3]([F-])6[F-])=C7[N]6=C(C)C=C7C |
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC 50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry , resulting in compound 8RK59 [1] .
UCHL1 (ubiquitin C-terminal hydrolase L1) [1]
8RK59 (5 μM, 24 h) binds only to wild-type UCHL1 but not to catalytically inactive UCHL1, indicating that the probe binding site is the active-site cysteine [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.
Arctom is a premier supply platform offering over 600K unique items of Building Blocks, Bioactive Molecules, Natural Products, ADC PEG Linkers, Antibodies, and other Research Chemicals for global pharmaceutical, biotech, university, and industrial customers. We accelerate your research by providing better and faster purchasing experience & services.