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[CAS NO. 274925-86-9] Nebicapone
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-106405 |
| Brand: | MCE |
| CAS: | 274925-86-9 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 273.24 |
| Molecular Formula | C14H11NO5 |
| SMILES | O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)CC2=CC=CC=C2 |
Summary
Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT , and it is potential for the treatment of Parkinson's disease [1] .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT02772614 | Bial - Portela C S.A. |
Parkinson´s Disease
|
January 2006 | Phase 1 |
| NCT02763839 | Bial - Portela C S.A. |
Parkinson´s Disease
|
April 2001 | Phase 1 |
| NCT03103399 | Bial - Portela C S.A. |
Parkinson Disease
|
September 26, 2006 | Phase 2 |
| NCT02778594 | Bial - Portela C S.A. |
Parkinson´s Disease (PD)
|
September 2005 | Phase 1 |
| NCT02774564 | Bial - Portela C S.A. |
Parkinson´s Disease
|
September 2005 | Phase 1 |
| NCT02779348 | Bial - Portela C S.A. |
Healthy
|
September 2006 | Phase 1 |
| NCT02772627 | Bial - Portela C S.A. |
Parkinson´s Disease
|
September 2001 | Phase 1 |
| NCT03097211 | Bial - Portela C S.A. |
Parkinson Disease
|
July 17, 2006 | Phase 1 |
| NCT02763852 | Bial - Portela C S.A. |
Parkinson´s Disease
|
April 2001 | Phase 1 |
| NCT02834507 | Bial - Portela C S.A. |
Parkinson´s Disease (PD)
|
March 2005 | Phase 2 |
| NCT02763800 | Bial - Portela C S.A. |
Parkinson´s Disease
|
September 2000 | Phase 1 |
| NCT02763787 | Bial - Portela C S.A. |
Parkinson´s Disease
|
April 2000 | Phase 1 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 365.98 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6598 mL | 18.2989 mL | 36.5979 mL |
| 5 mM | 0.7320 mL | 3.6598 mL | 7.3196 mL |
| 10 mM | 0.3660 mL | 1.8299 mL | 3.6598 mL |
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1.
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