[CAS NO. 2761367-25-1] Antiviral agent 25

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PRODUCTS SPECIFICATIONS [2761367-25-1]

Catalog

HY-152589

Brand

MCE

CAS

2761367-25-1

DESCRIPTION [2761367-25-1]

Overview

MDL	-
Molecular Weight	285.34
Molecular Formula	C15H12FN3S
SMILES	C/N=C1N=C(N(S\1)C2=CC=CC=C2)C3=CC=C(C=C3)F

For research use only. We do not sell to patients.

Summary

Antiviral agent 25 (compound 6g) is a new non-peptide analog covalent inhibitor of SARS-CoV-2 3CL ^pro . Antiviral agent 25 has a strong inhibitory effect on SARS-CoV-2 3CL ^pro and SARS-CoV-2 PL ^pro with IC ₅₀ values of 0.118 µM, 0.448 µM, respectively. Antiviral agent 25 has antiviral effect on SARS-CoV-2 with an EC ₅₀ value of 7.249 µM ^[1] .

IC50 & Target

SARS-CoV-2 3CL ^pro

0.118 μM (IC ₅₀ )

SARS-CoV-2 PL ^pro

0.448 μM (IC ₅₀ )

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Ren P, et al. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2. Eur J Med Chem. 2023 Jan 18;249:115129.