[CAS NO. 2771211-71-1] HIV-1 inhibitor-54

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PRODUCTS SPECIFICATIONS [2771211-71-1]

Catalog

HY-152539

Brand

MCE

CAS

2771211-71-1

DESCRIPTION [2771211-71-1]

Overview

MDL	-
Molecular Weight	534.63
Molecular Formula	C27H30N6O4S
SMILES	CC1=CC=CC(C)=C1OC2=CC=NC(NC3CCN(CC3)C(C4=CC5=C(N4)C=CC(NS(C)(=O)=O)=C5)=O)=N2

For research use only. We do not sell to patients.

Summary

HIV-1 inhibitor-54 is a potent HIV-1 inhibitor. HIV-1 inhibitor-54 has anti-HIV activity in MT-4 cells against WT HIV-1 (strain IIIB) with an EC ₅₀ value of 0.032 μM. HIV-1 inhibitor-54 can be used for the research of virus infection ^[1] .

IC50 & Target

HIV-1

In Vitro

HIV-1 inhibitor-54 (compound 4c) has potent activities against reverse transcriptase (RT) HIV-1 mutants E138K, K103 N, Y188L, Y181C, F227L+V106A and L100I with EC ₅₀ values of 0.080, 0.52, 0.67, 0.84, 2.7 and 3.3 μM, respectively ^[1] .
HIV-1 inhibitor-54 inhibits WT HIV-1 RT activity with an IC ₅₀ value of 12 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Ming W, et al. Hybrids of delavirdine and piperdin-4-yl-aminopyrimidines (DPAPYs) as potent HIV-1 NNRTIs: Design, synthesis and biological activities. Eur J Med Chem. 2023 Feb 15;248:115114.