[CAS NO. 278605-15-5] p-Ethynylphenylalanine
PRODUCTS SPECIFICATIONS [278605-15-5]
DESCRIPTION [278605-15-5]
Overview
| MDL | MFCD18252809 |
|---|---|
| Molecular Weight | 189.21 |
| Molecular Formula | C11H11NO2 |
| SMILES | N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O |
1 Publications Citing Use of MCE
Summary
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM [1] .
IC50 & Target
Ki: 32.6 μM (TPH) [1]
In Vitro
p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin
[1]
.
p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT
1
, 5-HT
2
, 5-HT
4
, 5-HT
5
, 5-HT
6
, and 5-HT
7
)
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue
[1]
.
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Sprague-Dawley rats (200 g) [1] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
1M NaOH : 240 mg/mL ( 1268.43 mM ; ultrasonic and adjust pH to 11 with NaOH)
1M HCl : 240 mg/mL ( 1268.43 mM ; ultrasonic and adjust pH to 1 with HCl)
DMSO : 2.22 mg/mL ( 11.73 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.2851 mL | 26.4257 mL | 52.8513 mL |
| 5 mM | 1.0570 mL | 5.2851 mL | 10.5703 mL |
| 10 mM | 0.5285 mL | 2.6426 mL | 5.2851 mL |