[CAS NO. 2834087-82-8] HIV-1 inhibitor-51
PRODUCTS SPECIFICATIONS [2834087-82-8]
DESCRIPTION [2834087-82-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 463.89 |
| Molecular Formula | C24H19ClFN5O2 |
| SMILES | FC(C=C1NC2=NC(OC3=C(C=C(C=C3C)/C=C/C#N)C)=C4C(COC4)=N2)=C(C=C1)C#N.Cl |
Summary
HIV-1 inhibitor-51, a non-nucleoside reverse transcriptase inhibitor (NNRTI) , exhibits outstanding antiviral activity against WT HIV-1 (IIIB) and a panel of mutant strains. HIV-1 inhibitor-51 has high binding affinity ( K D =2.50 μM) and inhibitory activity ( IC 50 =0.03 μM) to WT HIV-1 RT. HIV-1 inhibitor-51 has EC 50 s of 2.22-53.3 nM for mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056) [1] .
IC50 & Target
|
HIV-1 (WT) 0.03 μM (IC 50 ) |
HIV-1 (WT) 2.5 μM (Kd) |
HIV-1 (L100I) 3.04 nM (EC 50 ) |
HIV-1 (K103N) 2.87 nM (EC 50 ) |
HIV-1 (Y181C) 10.2 nM (EC 50 ) |
|
|
HIV-1 (Y188L) 13.2 nM (EC 50 ) |
HIV-1 (E138K) 9.77 nM (EC 50 ) |
HIV-1 (F227L+V106A) 19.8 nM (EC 50 ) |
HIV-1 (RES056) 53.3 nM (EC 50 ) |
||
In Vivo
HIV-1 inhibitor-51 (compound 36a·HCl; 2 mg/kg; iv) has a T
1/2
of 1.43 hours, a CL of 103 L/h·kg, and C
max
of 484 ng/mL
[1]
.
HIV-1 inhibitor-51 (10 mg/kg; orally) has a T
1/2
of 5.12 hours, and C
max
of 37.5 ng/mL
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | ICR mice [1] |
| Dosage: | 2 mg/kg (Pharmacokinetic Analysis) |
| Administration: | IV |
| Result: | Had a T 1/2 of 5.12 hours, and C max of 37.5 ng/mL. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.