[CAS NO. 2869954-34-5] HRO761

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PRODUCTS SPECIFICATIONS [2869954-34-5]

Catalog

HY-148699

Brand

MCE

CAS

2869954-34-5

DESCRIPTION [2869954-34-5]

Overview

MDL	-
Molecular Weight	702.08
Molecular Formula	C31H31ClF3N9O5
SMILES	O=C(N1CCN(CC1)C2=C(CC)N(CC(NC3=CC=C(C(F)(F)F)C=C3Cl)=O)C4=NC(C5=CCOCC5)=NN4C2=O)C6=NC=NC(C)=C6O

For research use only. We do not sell to patients.

Summary

Werner syndrome RecQ helicase-IN-1 (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme ( WRN ) inhibitor and can be used in cancer research ^[1] .

In Vitro

Werner syndrome RecQ helicase-IN-1 (example 42) has an IC ₅₀ value of 100 nM for WRN ATPase and GI ₅₀ values of 50 nM and >10 μM for SW48 and DLD1 WRN-KO cell lines, respectively ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060