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Catalog: | HY-148837 |
Brand: | MCE |
CAS: | 2883535-99-5 |
MDL | - |
---|---|
Molecular Weight | 614.65 |
Molecular Formula | C35H30N6O5 |
SMILES | O=C(C1=CC=C2C(N(C3C(NC(CC3)=O)=O)CC2=C1)=O)NCC4=CC=C(CNC(CN5C6=C(C7=CC=CC=C75)C=CC=N6)=O)C=C4 |
c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC , CK1α , GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer , cardiovascular and cerebrovascular diseases, and viral infection [1] .
c-Myc inhibitor 7 (0-10 mM; 3 days) inhibits cell proliferation of HL60 cells with an IC
50
value of 0.5 nM
[1]
.
c-Myc inhibitor 7 promotes 60-90% cell protein degradation of HL60 cells
[1]
.
c-Myc inhibitor 7 (1, 3, 10 and 100 nM; 24 hours) degrades c-Myc, CKla, GSPTl, IKZFl , IKZF2 and IKZF3 proteins in multi-cell lines
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Room temperature in continental US; may vary elsewhere.
Please store the product under the recommended conditions in the Certificate of Analysis.
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