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[CAS NO. 2921-57-5] Methylprednisolone succinate
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1900 |
| Brand: | MCE |
| CAS: | 2921-57-5 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 474.54 |
| Molecular Formula | C26H34O8 |
| SMILES | C[C@@]12[C@](C(COC(CCC(O)=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O |
Summary
Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.
IC50 & Target
glucocorticoid receptor [1]
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04979650 | Mazandaran University of Medical Sciences |
Multiple Sclerosis, Relapsing-Remitting|Magnetic Resonance Imaging|Methylprednisolone
|
May 22, 2021 | Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 210.73 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.1073 mL | 10.5365 mL | 21.0730 mL |
| 5 mM | 0.4215 mL | 2.1073 mL | 4.2146 mL |
| 10 mM | 0.2107 mL | 1.0537 mL | 2.1073 mL |
References
- [1] Marchant A, et al. Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) productionduring murine endotoxaemia. Clin Exp Immunol. 1996 Oct;106(1):91-6.
- [2] Diem R, et al. Methylprednisolone increases neuronal apoptosis during autoimmune CNS inflammation by inhibition of an endogenous neuroprotective pathway. J Neurosci. 2003 Aug 6;23(18):6993-7000.
Synonyms
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