[CAS NO. 292633-16-0] Ac-LEHD-AMC

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PRODUCTS SPECIFICATIONS [292633-16-0]

Catalog

HY-D1652

Brand

MCE

CAS

292633-16-0

DESCRIPTION [292633-16-0]

Overview

MDL	-
Molecular Weight	711.72
Molecular Formula	C33H41N7O11
SMILES	CC(C1=CC=C(NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(C)C)=O)=O)CC2=CN=CN2)=O)=O)C=C1O3)=CC3=O

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Summary

Ac-LEHD-AMC is a fluorogenic substrate for caspase-9 (Excitation: 341 nm; Emission: 441 nm). Caspase-9 can induce hydrolysis of Ac-LEHD-AMC, resulting in the release of AMC fluorophore and its fluorescence can be used to quantify caspase-9 activity ^[1] .

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References

[1] Igor M Prudnikov, et al. Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. J Biochem. 2012 Mar;151(3):299-316.