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[CAS NO. 29477-83-6] Narciclasine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-16563 |
| Brand: | MCE |
| CAS: | 29477-83-6 |
Overview
| MDL | MFCD01729949 |
|---|---|
| Molecular Weight | 307.26 |
| Molecular Formula | C14H13NO7 |
| SMILES | O=C1N[C@@]2([H])[C@H](O)[C@H](O)[C@@H](O)C=C2C3=C1C(O)=C4C(OCO4)=C3 |
9 Publications Citing Use of MCE
- [1]Clin Transl Med. 2022 Jun;12(6):e850.
- [2]Acta Biomater. 2021 Sep 4;S1742-7061(21)00586-9.
- [3]iScience. 2019 May 31;15:291-306.
- [4]Cell Immunol. 15 October 2022, 104631.
- [5]Life Sci. 2019 Apr 15;223:54-61.
- [6]Biomed Res Int. 2021 May 15.
- [7]Exp Ther Med. 2022 May;23(5):355.
- [8]Hong Kong Polytechnic University. Department of Biomedical Engineering. 2021 Nov.
- [9]Heliyon. 2020 Dec;6(12):e05646.
Summary
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
IC50 & Target
|
ROCK
|
In Vitro
Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC 50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC 50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines [1] . Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC 50 measured for radicle growth inhibition is 0.1 µM for Narciclasine [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 26 mg/mL ( 84.62 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2546 mL | 16.2729 mL | 32.5457 mL |
| 5 mM | 0.6509 mL | 3.2546 mL | 6.5091 mL |
| 10 mM | 0.3255 mL | 1.6273 mL | 3.2546 mL |
References
- [1] Lefranc F, et al. Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells. Mol Cancer Ther. 2009 Jul;8(7):1739-50.
- [2] Wahyuni DS, et al. The use of bio-guided fractionation to explore the use of leftover biomass in Dutch flower bulb production as allelochemicals against weeds. Molecules. 2013 Apr 17;18(4):4510-25.
Synonyms
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