[CAS NO. 29557-51-5] Dodecylphosphocholine
PRODUCTS SPECIFICATIONS [29557-51-5]
DESCRIPTION [29557-51-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 351.46 |
| Molecular Formula | C17H38NO4P |
| SMILES | O=P([O-])(OCC[N+](C)(C)C)OCCCCCCCCCCCC |
Summary
In Vitro
Dodecylphosphocholine micelles can be used to characterize pore formation the influenza M2 transmembrane (M2TM) domain by NMR spectroscopy [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 31.25 mg/mL ( 88.91 mM ; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.8453 mL | 14.2264 mL | 28.4527 mL |
| 5 mM | 0.5691 mL | 2.8453 mL | 5.6905 mL |
| 10 mM | 0.2845 mL | 1.4226 mL | 2.8453 mL |
References
- [1] de Haas GH, Dijkman R, Ransac S, Verger R. Competitive inhibition of lipolytic enzymes. IV. Structural details of acylamino phospholipid analogues important for the potent inhibitory effects on pancreatic phospholipase A2. Biochim Biophys Acta. 1990;1046(3):249-257.
- [2] François Dehez, et al. Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity. Biophys J. 2017 Dec 5;113(11):2311-2315.
- [3] Sarah D Cady, et al. Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc. 2011 Mar 30;133(12):4274-84.