[CAS NO. 300851-67-6] 4-CMTB
PRODUCTS SPECIFICATIONS [300851-67-6]
DESCRIPTION [300851-67-6]
Overview
| MDL | MFCD02666163 |
|---|---|
| Molecular Weight | 294.80 |
| Molecular Formula | C14H15ClN2OS |
| SMILES | O=C(NC1=NC=CS1)C(C(C)C)C2=CC=C(Cl)C=C2 |
2 Publications Citing Use of MCE
Summary
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator ( pEC 50 =6.38) [1] .
In Vitro
4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2) [1] [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL ( 339.21 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3921 mL | 16.9607 mL | 33.9213 mL |
| 5 mM | 0.6784 mL | 3.3921 mL | 6.7843 mL |
| 10 mM | 0.3392 mL | 1.6961 mL | 3.3921 mL |
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Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.48 mM); Clear solution
References
- [1] Smith NJ, et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011;80(1):163-173.
- [2] Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153.