[CAS NO. 301298-87-3] ZIM
PRODUCTS SPECIFICATIONS [301298-87-3]
DESCRIPTION [301298-87-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 349.38 |
| Molecular Formula | C20H19N3O3 |
| SMILES | CC1=C(C(N(N1C)C2=CC=CC=C2)=O)N3C(C4C5C=CC(C4C3=O)C5)=O |
Summary
In Vivo
ZIM (i.p., 12, 24 and 48 mg/kg) can effectively reduce the frequency of chromosome micronucleus at all doses at 24 and 72 h in adult male Swiss mice, and has certain chemoprophylaxis effect, and the percentage of damage reduction ranges from 38.36 to 83.26%
[1]
.
ZIM (i.p., 12, 24 and 48 mg/kg) reduces the frequency of cisplatin-CIS and doxorubicin-DOX-induced liver and kidney cell death. At 12, 24 and 48 mg/kg dosages, the percentage of liver damage reduction in CIS group are 79.27, 75.20 and 52.84%, and that in DOX group are 62.06, 59.44 and 77.80%, respectively. The reduction percentages of kidney injury in CIS group are 45.29, 36.09 and 41.61%, and those in DOX group are 28.00, 21.41 and 30.82%, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.