[CAS NO. 30408-07-2] JB002

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PRODUCTS SPECIFICATIONS [30408-07-2]

Catalog

HY-152190

Brand

MCE

CAS

30408-07-2

DESCRIPTION [30408-07-2]

Overview

MDL	-
Molecular Weight	293.32
Molecular Formula	C18H15NO3
SMILES	C/C(C1=C(C2=CC=CC=C2OC1=O)O)=N\CC3=CC=CC=C3

For research use only. We do not sell to patients.

Summary

JB002 is a myosin II inhibitor, with an IC ₅₀ of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy ^[1] .

IC50 & Target

IC50: ≤10 μM (myosin II) ^[1]

In Vitro

JB002 show promising selectivity between cardiac and skeletal myosin but have no detectible activity toward nonmuscle IIB ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1] Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.