[CAS NO. 306301-68-8]  SKI-I

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PRODUCTS SPECIFICATIONS [306301-68-8]

Catalog
HY-115735
Brand
MCE
CAS
306301-68-8

DESCRIPTION [306301-68-8]

Overview

MDL-
Molecular Weight406.44
Molecular FormulaC25H18N4O2
SMILESO=C(C1=NNC(C2=CC=C3C=CC=CC3=C2)=C1)N/N=C/C4=C5C=CC=CC5=CC=C4O

For research use only. We do not sell to patients.

Summary

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK) , with an IC 50 of 1.2 μM for ST-hSK . SKI-I also inhibits hERK2 ( IC 50 =11 μM). SKI-I induces apoptosis in tumor cell lines [1] [2] .


IC50 & Target

IC50: 1.2 μM (ST-hSK); 11 μM (hERK2) [1]


In Vitro

SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99% [1] .
SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)


Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 246.04 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4604 mL 12.3019 mL 24.6039 mL
5 mM 0.4921 mL 2.4604 mL 4.9208 mL
10 mM 0.2460 mL 1.2302 mL 2.4604 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.15 mM); Clear solution

* All of the co-solvents are available by MCE.