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[CAS NO. 309928-48-1] KL001
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-108468 |
| Brand: | MCE |
| CAS: | 309928-48-1 |
Overview
| MDL | MFCD02086647 |
|---|---|
| Molecular Weight | 398.48 |
| Molecular Formula | C21H22N2O4S |
| SMILES | CS(=O)(N(CC(O)CN1C2=C(C3=C1C=CC=C3)C=CC=C2)CC4=CC=CO4)=O |
Summary
KL001 is a first-in-class cryptochrome ( CRY , a flavoproteins that are sensitive to blue light , and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis [1] [2] [3] .
In Vitro
KL001 (0.03-71 μM) causes circadian period lengthening and amplitude reduction in a dose-dependent manner in stable U2OS reporter cell lines harboring
Bmal1-dLuc
or
Per2-dLuc
[1]
.
KL001 (2-8 μM; 18 h) represses glucagon-dependent induction of
Pck1
and
G6pc
genes in a dose-dependent manner without affecting their basal expression in mouse primary hepatocytes
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 5 mg/mL ( 12.55 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5095 mL | 12.5477 mL | 25.0954 mL |
| 5 mM | 0.5019 mL | 2.5095 mL | 5.0191 mL |
| 10 mM | 0.2510 mL | 1.2548 mL | 2.5095 mL |
References
- [1] Hirota T, et, al. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31;337(6098):1094-7.
- [2] Kelleher FC, et, al. Circadian molecular clocks and cancer. Cancer Lett. 2014 Jan 1;342(1):9-18.
- [3] Nangle S, et, al. Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase. Cell Res. 2013 Dec;23(12):1417-9.
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