[CAS NO. 31121-93-4] Ibuprofensodium

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PRODUCTS SPECIFICATIONS [31121-93-4]

Catalog

HY-78131C

Brand

MCE

CAS

31121-93-4

DESCRIPTION [31121-93-4]

Overview

MDL	-
Molecular Weight	228.26
Molecular Formula	C13H17NaO2
SMILES	O=C(O[Na])C(C)C1=CC=C(CC(C)C)C=C1

For research use only. We do not sell to patients.

8 Publications Citing Use of MCE

Summary

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC ₅₀ value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis . Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection , immunology, cancers ^[1] ^[2] ^[5] ^[8] .

IC50 & Target

COX-1

13 μM (IC ₅₀ )

COX-2

370 μM (IC ₅₀ )

In Vitro

Ibuprofen sodium (24 h) inhibits COX-1 and COX-2 activity with IC ₅₀ values of 13 μM and 370 μM ^[1] .
Ibuprofen sodium (500 μM, 48 h) inhibits cell proliferation and angiogenesis, and induces apoptosis in AGS cells (Adenocarcinoma gastric cell line) ^[2] .
Ibuprofen sodium (500 μM, 48 h) downregulates transcription of Akt, VEGF-A, PCNA, Bcl2, OCT3/4 and CD44 genes, but upregulates RNA levels of wild type P53 and Bax genes in AGS cell ^[2] .
Ibuprofen sodium (500 μM, 24 h) restores microtubule reformation, microtubule-dependent intracellular cholesterol transport, and induces extension of microtubules to the cell periphery in both cystic fibrosis (CF) cell models and primary CF nasal epithelial cells ^[3] .
Ibuprofen sodium (500 μM, 24 h) enhances UV-induced cell death in MCF-7 cells and MDA-MB-231 cells by a photosensitization process ^[4] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[2]

Cell Line:	AGS cells
Concentration:	100-1000 μM
Incubation Time:	24 h, 48 h
Result:	Inhibited AGS cell viability with IC ₅₀ values of 630 μM (trypan blue staining, 24 h), 456 μM (neutral red assay, 24 h), 549 μM (trypan blue staining , 48 h) and 408 μM (neutral red assay, 48 h).

In Vivo

Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer ^[5] .
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatin‑induced peripheral neuropathy ^[6] .
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise ^[7] .
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection ^[8] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum) ^[5]
Dosage:	300 mg/kg, daily for 14 days
Administration:	Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
Result:	Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells. Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.

Animal Model:	Oxaliplatin‑induced peripheral neuropathy ^[6]
Dosage:	60 mg/kg, every second day for 15 days
Administration:	Subcutaneous injection
Result:	Lowered sensory nerve conduction velocity (SNCV).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT02417506	Vedic Lifesciences Pvt. Ltd.\|Enovate Biolife Pvt Ltd	Osteoarthritis of Knee	August 2014	Not Applicable
NCT00092755	Organon and Co	Osteoarthritis	April 9, 2003	Phase 3
NCT00707057	SCOLR Pharma, Inc.\|AAIPharma\|Jean Brown Research	Pain\|Post-Operative Pain\|Third Molar Extraction	June 2008	Phase 3
NCT00239746	National Institute on Aging (NIA)	Alzheimer´s Disease	October 2005	Phase 1
NCT01030666	Peter Eickholz\|Heidelberg University\|Dr. August Wolff GmbH & Co. KG Arzneimittel\|Gaba International AG\|Goethe University	Periodontitis	April 2007	Phase 4
NCT01789606	Pfizer	Analgesia	September 24, 2012	Phase 3
NCT02935894	USDA, Western Human Nutrition Research Center\|University of California, Davis	Stability & Variability of Lipid-derived Molecules in Sweat	November 28, 2016	Not Applicable
NCT03822962	University of Nebraska	Nasal Sinus; Inflammation\|Opioid Abuse\|Pain, Postoperative	November 7, 2020	Early Phase 1
NCT04976387	Loma Linda University	Postoperative Pain\|Patient Satisfaction\|Analgesia	July 2, 2021	Phase 3
NCT02330926	Norwegian University of Science and Technology\|St. Olavs Hospital\|Oslo University Hospital\|Cantonal Hospital of St. Gallen\|Ottawa Regional Cancer Centre\|Jewish General Hospital\|Cross Cancer Institute\|The Beatson West of Scotland Cancer Centre\|Queen Margaret Hospital, Dunfermline\|Cancer Research UK Edinburgh Centre\|Malteser Krankenhaus Seliger Gerhardt\|Tumor Biology Center Freiburg\|Tumor Zentrum Aarau\|Chelsea and Westminister Hospital NHS\|Cedars-Sinai Medical Center\|Guy´s and St Thomas´ NHS Foundation Trust\|NHS Forth Valley	Cachexia\|Neoplasms	April 2015	Phase 3
NCT03789058	Jordan University of Science and Technology\|McGill University\|InterPharma One LLC	Operation Site Inflammation\|Pain, Postoperative\|Teeth, Impacted	April 19, 2018	Phase 2\|Phase 3
NCT02932579	University of Rochester	Pain	July 1, 2017	Phase 4
NCT01426971	Sanofi	Pain	December 2012	Phase 3
NCT01953978	Rigshospitalet, Denmark\|Glostrup University Hospital, Copenhagen	Pain	December 2012	Phase 4
NCT04271917	University of Tennessee	Pain, Acute	February 24, 2020	Phase 3
NCT01716052	Kenneth A. Kist,\|The University of Texas Health Science Center at San Antonio	Pain	July 2012	Not Applicable
NCT01530880	Columbia University\|Cumberland Pharmaceuticals	Fever	October 2012	Phase 4
NCT05048914	Bnai Zion Medical Center	Migraine Disorders	September 3, 2019
NCT01171794	Stanford University\|University of California, San Diego	Altitude Sickness	July 2010	Phase 3
NCT01595282	Planned Parenthood League of Massachusetts\|Society of Family Planning	Pain	June 2011	Not Applicable
NCT04523623	Washington University School of Medicine	Forearm Injuries\|Pain, Acute\|Pediatric ALL	September 2020	Not Applicable
NCT02461056	Samsung Medical Center	Breast Cancer	June 2014	Not Applicable
NCT01988298	Complejo Hospitalario Dr. Arnulfo Arias Madrid	Hypertension	October 2013	Phase 2\|Phase 3
NCT02580344	Assiut University	Contraception	October 2015	Phase 2
NCT02583399	Cumberland Pharmaceuticals	Pain\|Fever	August 8, 2017	Phase 4
NCT03691818	Tianjin XinChen-Techfields Pharma Co., LTD.	KNEE OSTEOARTHRITIS	July 16, 2018	Phase 2
NCT03622489	Wolfson Medical Center	Postoperative Pain\|Post-Cesarean Section	March 1, 2017	Phase 4
NCT02256423	Simbec Research	Healthy Volunteer Study	July 2014	Phase 1
NCT01268670	Children´s Hospitals and Clinics of Minnesota	Laceration\|Pain	July 2012	Not Applicable
NCT05190341	Madigan Army Medical Center	Infertility, Female	January 31, 2022	Phase 4
NCT02110719	Hartford Hospital	Narcotic Use\|Pain\|Constipation\|Nausea	March 2014	Phase 4
NCT02668822	Organon and Co	Dysmenorrhea	February 9, 2016	Phase 3
NCT02064894	St. Justine´s Hospital	Musculoskeletal Injury	July 8, 2013	Not Applicable
NCT03861611	Montefiore Medical Center	Back Pain Without Radiation\|Low Back Pain	July 12, 2019	Phase 4
NCT00642330	Hopital La Rabta\|maternity and neonatal center	Patent Ductus Arteriosus	January 2007	Phase 4
NCT03695367	Heron Therapeutics	Postoperative Pain	October 1, 2018	Phase 2
NCT01562717	Orion Corporation, Orion Pharma	Pain	February 2012	Phase 3
NCT02155166	University of Sao Paulo\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Pain	February 2012	Not Applicable
NCT02929589	Mike O´Callaghan Military Hospital	Pain\|Hernia	July 5, 2018	Phase 3
NCT03949478	University of Calgary	Epilepsy\|Epilepsies, Partial	February 1, 2021	Phase 2
NCT01680939	Hamilton Health Sciences Corporation\|The Hospital for Sick Children\|University of Western Ontario, Canada	Pediatric Obstructive Sleep Apnea Syndrome	May 2012	Phase 3
NCT02468297	Chen Yu Sheng\|Chang Gung Memorial Hospital	Low Back Pain	April 15, 2009	Not Applicable
NCT01690780	Naveen Poonai\|Lawson Health Research Institute	Upper Extremity Fractures\|Analgesia Post Fracture	September 2012	Not Applicable
NCT02891174	University of Michigan	Hypertension, Pregnancy-Induced\|Pre-eclampsia	December 1, 2016	Phase 4
NCT01235949	GlaxoSmithKline	Infections, Streptococcal	November 12, 2010	Phase 4
NCT00619307	Merck KGaA, Darmstadt, Germany	Relapsing Multiple Sclerosis	July 2007	Phase 3
NCT03929640	Milton S. Hershey Medical Center	Pain, Postoperative\|Opioid Use	August 5, 2019	Phase 3
NCT02443142	Northwestern University\|Northwestern Memorial Hospital	Brain Concussion	May 1, 2015	Phase 2
NCT03418805	Overseas Pharmaceuticals, Ltd.\|Virginia Contract Research Organization Co., Ltd.	Pain Control	December 11, 2017	Phase 1
NCT02056223	University of Padova	Ductus Arteriosus Patent\|Respiratory Distress Syndrome	January 9, 2017	Phase 2\|Phase 3
NCT01332253	Cumberland Pharmaceuticals	Tonsillectomy	July 2011	Phase 3
NCT01436188	Janssen Research & Development, LLC	Healthy\|Alzheimer Disease	September 2011	Early Phase 1
NCT01849926	University of Oslo\|University of Bergen\|Lund University\|University of Copenhagen	Acute Cystitis (Excl in Pregnancy)	April 2013	Phase 4
NCT04059172	University of Colorado, Denver	Pain, Orofacial	December 10, 2019	Early Phase 1
NCT01316978	McNeil AB\|Johnson & Johnson Consumer and Personal Products Worldwide	Pain	February 2011	Phase 1
NCT03060434	St Joseph University, Beirut, Lebanon	Lumbar Radiculopathy\|Lumbar Disc Herniation\|Lumbar Disc Disease	June 1, 2018	Phase 4
NCT01785862	Pierre Fabre Medicament	Acute Sore Throat Pain	February 2013	Phase 3
NCT02602483	Spherium Biomed\|Universitat Internacional de Catalunya\|Hospital Odontològic UB\|Hospital Universitario La Fe\|Hospital Universitario Rey Juan Carlos	Temporomandibular Joint Disorders	December 2015	Phase 1\|Phase 2
NCT00804440	Perrigo Company	Bioequivalency	January 2004	Phase 1
NCT00951561	Another Way Products	Dysmenorrhea	November 2006	Not Applicable
NCT00239512	China Medical University Hospital	Ductus Arteriosus, Patent\|Preterm Infants	March 2005	Not Applicable
NCT05575700	Naestved Hospital	Pain, Acute\|Hip Arthropathy\|Knee Arthropathy\|Safety Issues\|Analgesia\|Analgesic Adverse Reaction\|Postoperative Pain\|Postoperative Complications	April 1, 2023	Phase 4
NCT03265782	Ain Shams University	Patent Ductus Arteriosus	June 2015	Phase 4
NCT01457521	Gynuity Health Projects\|Society of Family Planning\|Family Planning Associates Medical Group, LTD\|Planned Parenthood of Greater New York	Pain	October 2011	Phase 4
NCT03011567	MemorialCare Health System	Hypertension, Pregnancy-Induced	January 2017	Not Applicable
NCT00402493	Philadelphia Eye Associates\|Pfizer	Glaucoma\|Ocular Hypertension	December 2006	Not Applicable
NCT04123873	Naestved Hospital	Pain, Acute\|Hip Arthropathy\|Analgesia\|Postoperative Pain	March 5, 2020	Phase 4
NCT01428180	University of Ulm	Prematurity of Fetus\|Patent Ductus Arteriosus	April 2011
NCT02531451	Karolinska Institutet	Skeletal Muscle Mass Regulation	September 2015	Phase 2
NCT02463383	Professor Lars Ove Dragsted\|Technical University of Denmark\|University of Copenhagen	Breast Cancer	September 2013	Early Phase 1
NCT04637529	Apsen Farmaceutica S.A.	Osteoarthritis	May 2022	Phase 2
NCT02187588	Boehringer Ingelheim	Pain	February 1998	Phase 2
NCT01535079	Pierre Fabre Medicament	Acute Sore Throat Pain	February 2012	Phase 2
NCT00895843	University of Manchester\|Manchester University NHS Foundation Trust	Postoperative Pain\|Wisdom Tooth	November 2006	Not Applicable
NCT00528658	Chinese University of Hong Kong\|Hong Kong Academy of Medicine	Soft Tissue Injuries	January 2005	Phase 2
NCT04282941	Instituto de Investigación Hospital Universitario La Paz	Persistent Ductus Arteriosus	February 20, 2017	Phase 3
NCT03648437	University of Oulu\|Helsinki University Central Hospital\|Turku University Hospital\|Tartu University Hospital	Patent Ductus Arteriosus	September 3, 2018	Phase 1
NCT04018768	NYU Langone Health	Shoulder Pain	December 1, 2017
NCT01586299	Rabin Medical Center	Pleuro-pneumonia	March 2012	Not Applicable
NCT03223519	Spherium Biomed\|Fundació Institut de Recerca de l´Hospital de la Santa Creu i Sant Pau	Delayed Onset Muscle Soreness, DOMS	July 12, 2017	Phase 2
NCT03055507	University of Washington	Chronic Rhinosinusitis (Diagnosis)	April 1, 2017	Phase 2\|Phase 3
NCT01490905	Targeted Medical Pharma	Chronic Low Back Pain	September 2010	Phase 4
NCT02244437	Mountain Medicine Society of Nepal	Acute Mountain Sickness, Blood Oxygen Saturation, Headache	October 2014	Phase 4
NCT01972906	Chengdu University of Traditional Chinese Medicine	Primary Dysmenorrhea	February 2012	Early Phase 1
NCT05428306	Laboratorios Silanes S.A. de C.V.	Healthy	October 23, 2018	Phase 1
NCT00531882	University Hospitals Cleveland Medical Center	Cystic Fibrosis	September 2007	Not Applicable
NCT02227316	University of California, Los Angeles\|Sponsor Name Pending	Symptomatic Uterine Fibroids and Adenomyosis	August 2014	Phase 4
NCT03243032	Satheesh Elangovan\|University of Iowa	Pain, Postoperative	October 6, 2017	Early Phase 1
NCT02006576	University of Nebraska\|National Jewish Health\|Temple University\|University of California, Los Angeles\|University of Alabama at Birmingham	Emphysema	January 2014	Phase 2
NCT03352362	Yonsei University	Inguinal Hernia	December 15, 2017	Not Applicable
NCT04813991	Hackensack Meridian Health	Perioperative Pain	March 15, 2022	Phase 3
NCT04791761	David Chi, MD\|University of Pittsburgh	Adenotonsillectomy\|Post-operative Analgesia\|Opioid Use	April 13, 2021	Phase 1\|Phase 2
NCT01478022	Parent Project, Italy	Duchenne Muscular Dystrophy (DMD)	October 2011	Phase 1
NCT02096926	Lotus Clinical Research, LLC	Dental Pain	March 2014	Phase 4
NCT05488847	Henry Ford Health System	Shoulder Arthropathy\|Shoulder Pain	June 25, 2022	Phase 4
NCT03749616	University of Missouri-Columbia	Distal Radius Fracture	January 2, 2019	Phase 4
NCT04947566	Fatima Memorial Hospital	Pain, Postoperative	September 2, 2019	Phase 4
NCT03372382	The University of Texas Health Science Center, Houston	Opioid Use\|Pain, Postoperative	December 13, 2017	Phase 4
NCT01605240	University of Manitoba	Fracture\|Pain	July 2012	Not Applicable
NCT04423107	University of Oklahoma	Hypospadias	July 1, 2020	Phase 3
NCT02836509	Pamukkale University	Low Back Pain	September 2016	Phase 4
NCT04070001	Ye?im KAYA\|Yuzuncu Y?l University	Crowding, Tooth	August 1, 2017	Not Applicable
NCT02807623	Womack Army Medical Center\|United States Department of Defense	Immune System and Related Disorders	September 2016	Not Applicable
NCT02373254	University of California, Davis	Ankle Fracture	January 2015	Early Phase 1
NCT04213924	Ataturk University	Urinary System Stones\|Pain	June 1, 2020	Not Applicable
NCT01462370	Organon and Co	Dysmenorrhea	November 2011	Phase 3
NCT02152163	Delray Medical Center	Pain	October 2012	Phase 4
NCT03332524	Sephoris Pharmaceuticals LLC	Sunburn	January 15, 2018	Phase 2
NCT01555476	McNeil AB\|Johnson & Johnson Consumer and Personal Products Worldwide	Pain	February 2012	Phase 1
NCT05340582	Mount Sinai Hospital, Canada\|Sunnybrook Health Sciences Centre\|McMaster Children´s Hospital\|The Rotunda Hospital	Patent Ductus Arteriosus After Premature Birth	November 2022	Phase 2
NCT04227652	University Hospital Ostrava	Sepsis\|Severe Sepsis\|Septic Shock	September 3, 2013	Not Applicable
NCT01681667	Albany Medical College	Pharyngitis	September 2013	Phase 4
NCT01874626	Strategic Science & Technologies, LLC	Acute Ankle Sprain	June 2013	Phase 3
NCT00986882	Novartis	Postoperative Pain	September 2009	Phase 2
NCT03063658	Ankara University	Acute Pain\|Postoperative Pain	February 1, 2017	Phase 4
NCT04025203	Francisco Unda Solano\|Universidad Europea de Madrid	Carpal Tunnel Syndrome	August 1, 2019	Phase 4
NCT03225352	Bayer	Moderate Pain	August 7, 2017	Phase 1
NCT05000281	Major Extremity Trauma Research Consortium	Tibia Fracture	September 14, 2021	Phase 3
NCT00699114	Ullevaal University Hospital\|University of Oslo\|Oslo University Hospital	Surgery	June 2007	Phase 4
NCT01758913	Taipei Medical University Hospital\|John H. Stroger Hospital\|China Medical University Hospital	Patent Ductus Arteriosus	February 2007	Not Applicable
NCT02272725	Stanford University	Acute Kidney Injury\|Exercise-associated Hyponatremia\|Perceived Exertion	March 2015	Phase 3
NCT01496326	BioChemics, Inc.	Osteoarthritis	February 2011	Phase 2
NCT00223691	Vanderbilt University\|Vanderbilt University Medical Center	Autonomic Failure\|Orthostatic Hypotension	March 2002	Phase 1
NCT04961268	Alfarabi Colleges	Symptomatic Irreversible Pulpitis	June 1, 2020	Not Applicable
NCT02974166	Instituto Brasileiro de Osteopatia	Temporomandibular Disorder	March 2012	Not Applicable
NCT05401916	Bezmialem Vakif University	Postoperative Pain Management	June 10, 2022	Not Applicable
NCT04328805	Universidad Europea de Madrid	Carpal Tunnel Syndrome\|Ibuprofen\|Pain Management\|Pain, Chronic	September 2020	Phase 4
NCT04570644	AZTherapies, Inc.	Healthy Volunteers\|Alzheimer Disease	August 28, 2020	Phase 1
NCT02089529	University Hospital of North Norway\|University of Tromso	Axial Spondyloarthritis	January 2014	Not Applicable
NCT01606319	Milton S. Hershey Medical Center\|National Heart, Lung, and Blood Institute (NHLBI)	Asthma\|Wheezing	February 2013	Phase 3
NCT00565084	Merck Sharp & Dohme LLC	Osteoarthritis, Knee	March 2007	Phase 1
NCT00938509	Soroka University Medical Center	Fever	July 2009	Phase 4
NCT05602064	Alexandria University	Post-operative Pain	November 1, 2022	Phase 4
NCT02974361	Oxford Pharmascience Ltd	Pharmacokinetics	December 2016	Phase 1
NCT03568721	Rio de Janeiro State University\|Conselho Nacional de Desenvolvimento Científico e Tecnológico	Pain	January 25, 2015	Phase 4
NCT00245375	Nova Scotia Health Authority\|McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.	Laparoscopic Cholecystectomy\|Inguinal Hernia\|Abdominal Hernia\|Umbilical Hernia	January 2005	Not Applicable
NCT05318521	Overseas Pharmaceuticals, Ltd.\|Virginia Contract Research Organization Co., Ltd.	Degenerative Arthritis	December 10, 2021	Phase 3
NCT02128191	Samsung Medical Center	Bronchopulmonary Dysplasia (BPD)	July 2014	Phase 2
NCT01099462	Assaf-Harofeh Medical Center	Fever	June 2007
NCT00820027	Organon and Co	Pain, Postoperative	December 15, 2008	Phase 3
NCT02276911	St. Joseph´s Hospital and Medical Center, Phoenix	Cervical Spondylosis\|Lumbar Spondylosis	March 1, 2015	Phase 2
NCT02076893	Children´s Hospitals and Clinics of Minnesota	Pain	March 2014	Phase 4
NCT00382083	Mountain States Tumor and Medical Research Institute	Breast Pain	March 2006	Phase 4
NCT02689063	AFT Pharmaceuticals, Ltd.	Post Operative Pain	October 26, 2016	Phase 3
NCT01707251	Jacobi Medical Center\|Cumberland Pharmaceuticals\|Sagatech Electronics Inc, Alberta, Canada	Obesity	October 2012	Phase 4
NCT00613106	Horizon Pharma Ireland, Ltd., Dublin Ireland	Osteoarthritis\|Rheumatoid Arthritis\|Chronic Low Back Pain\|Chronic Regional Pain Syndrome\|Chronic Soft Tissue Pain	September 2007	Phase 3
NCT04347720	IWK Health Centre\|Provincial Health Services Authority\|Children´s Hospital of Eastern Ontario\|CHU de Quebec-Universite Laval\|Foothills Medical Centre\|Victoria General Hospital\|The Hospital for Sick Children\|Health Sciences Centre, Winnipeg, Manitoba\|St. Justine´s Hospital\|Queen´s University\|MOUNT SINAI HOSPITAL\|Royal Alexandra Hospital\|Regina General Hospital\|Royal University Hospital Foundation\|St. Boniface Hospital\|The Moncton Hospital\|Horizon Health Network\|Sunnybrook Health Sciences Centre\|Windsor Regional Hospital\|Royal Columbian Hospital\|Centre de recherche du Centre hospitalier universitaire de Sherbrooke\|London Health Sciences Centre\|Canadian Institutes of Health Research (CIHR)	Patent Ductus Arteriosus\|Extreme Prematurity	January 1, 2020
NCT03180879	Reckitt Benckiser Healthcare (UK) Limited\|Simbec Research	Healthy	April 10, 2017	Phase 1
NCT02973958	Alberta Children´s Hospital	Pain, Postoperative\|Phimosis\|Paraphimosis\|Balanitis	February 1, 2017	Phase 1
NCT01830881	Oregon Health and Science University	Pain\|Anxiety\|Nausea	April 2013	Phase 4
NCT01131780	Dr. Reddy´s Laboratories Limited	Healthy	October 2004	Phase 1
NCT00625742	M.D. Anderson Cancer Center	Advanced Cancer\|Cachexia	February 2008	Not Applicable
NCT00792818	Mahidol University\|National Research Council of Thailand	Osteoarthritis	December 2008	Phase 3
NCT02902913	University of California, Davis\|USDA, Western Human Nutrition Research Center	Cardiovascular Diseases	January 2015	Not Applicable
NCT05325177	Ottawa Hospital Research Institute	Patent Ductus Arteriosus After Premature Birth	June 1, 2022	Phase 4
NCT05126264	Universidad Complutense de Madrid\|McGill University	Tooth, Impacted\|Trismus\|Pain\|Inflammatory Response	December 10, 2021	Not Applicable
NCT00620867	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Osteoarthritis, Knee	October 2002	Phase 4
NCT00954200	Shaare Zedek Medical Center	Post Bronchoscopy Fever		Phase 2
NCT03694587	Medherant Ltd\|Cooperative Clinical Drug Research and Development AG (CCDRD AG)	Healthy	September 25, 2018	Phase 1
NCT03169127	University of Sao Paulo\|Fundação de Amparo à Pesquisa do Estado de São Paulo	Pain\|Other Surgical Procedures\|Impacted Third Molar Tooth	April 1, 2016	Phase 4
NCT04382768	Química Luar SRL\|National Council of Scientific and Technical Research, Argentina\|Centro de Excelencia en Productos y Procesos Córdoba	Coronavirus Infection\|Respiratory Disease\|SARS (Disease)	May 1, 2020	Not Applicable
NCT02689024	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|ZonMw: The Netherlands Organisation for Health Research and Development	Hip Fractures\|Anesthesia	May 2016	Phase 4
NCT01630278	Nantes University Hospital	Patent Ductus Arteriosus	March 2012	Phase 3
NCT02205489	Genzyme, a Sanofi Company\|Sanofi	Relapsing-remitting Multiple Sclerosis	October 2014	Phase 4
NCT01420666	AFT Pharmaceuticals, Ltd.	Osteoarthritis		Phase 3
NCT03022253	Postgraduate Institute of Medical Education and Research	Patent Ductus Arteriosus	March 2016	Phase 3
NCT01064726	Pfizer	Allergic Rhinitis	October 2009	Phase 1
NCT04611529	Montefiore Medical Center	Low Back Pain	March 2, 2021	Phase 4
NCT01966172	Rigshospitalet, Denmark	Analgesia\|Postoperative Pain	March 2007	Phase 4
NCT03080493	University of California, Davis\|Society of Family Planning	Abortion, Induced\|Cervical Preparation\|Pain	March 20, 2017	Phase 4
NCT03759028	University of California, Los Angeles	Supracondylar Humerus Fracture	February 26, 2019	Phase 4
NCT02593721	Universidad Europea de Madrid	Cervicobrachial Neuralgia	July 2015	Phase 2\|Phase 3
NCT01297829	St. Barnabas Medical Center\|Cumberland Pharmaceuticals	Postoperative Pain	February 2011	Phase 3
NCT02571361	Daniel Hägi-Pedersen\|Copenhagen Trial Unit, Center for Clinical Intervention Research\|Naestved Hospital	Pain, Postoperative	November 2015	Phase 4
NCT02260947	Pfizer	Healthy	October 2014	Phase 1
NCT03783312	Inonu University	Postoperative Pain\|Myalgia\|Headache	December 20, 2018	Not Applicable
NCT02349607	Pfizer	Healthy	January 2015	Phase 1
NCT04429282	Yi Feng, MD\|Peking University People´s Hospital	Ibuprofen\|Nonsteroidal Anti-inflammatory Drug\|Intravenous\|Injectable\|Pain\|Analgesic	June 10, 2020	Phase 3
NCT00803946	Perrigo Company	Bioequivalency	November 2003	Phase 1
NCT02806869	University of Michigan\|Food and Drug Administration (FDA)	Human Gastrointestinal Physiology Data	January 2015	Not Applicable
NCT00267293	Penn State University\|Children Youth and Family Consortium	Fever	January 2006	Phase 4
NCT03918135	Pamukkale University	Fever	January 1, 2019	Phase 4
NCT02863575	Pfizer	Pain	October 24, 2017	Phase 3
NCT00219895	Ramsey, Bonnie, MD\|Cystic Fibrosis Foundation	Cystic Fibrosis	August 2004	Not Applicable
NCT01837810	Brooke Army Medical Center\|Madigan Army Medical Center\|Tripler Army Medical Center\|59th Medical Wing\|Blanchfield Army Community Hospital	Secondary Post Tonsillectomy Hemorrhage\|Primary Post Tonsillectomy Hemorrhage	April 2013	Not Applicable
NCT04111315	University Hospital Inselspital, Berne	Low Back Pain	December 15, 2019	Phase 4
NCT05479175	Yuzuncu Y?l University	Postoperative Pain	May 1, 2022	Not Applicable
NCT00662896	NicOx	Osteoarthritis\|Hypertension	March 2008	Phase 1
NCT04609254	Pamukkale University	Low Back Pain, Mechanical	December 15, 2018	Phase 4
NCT04681105	City of Hope Medical Center\|National Cancer Institute (NCI)	Recurrent Acute Leukemia\|Recurrent B Acute Lymphoblastic Leukemia\|Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm\|Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive\|Recurrent Hairy Cell Leukemia\|Recurrent Hematologic Malignancy\|Recurrent Hodgkin Lymphoma\|Recurrent T Acute Lymphoblastic Leukemia\|Refractory Acute Leukemia\|Refractory B Acute Lymphoblastic Leukemia\|Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm\|Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive\|Refractory Hairy Cell Leukemia\|Refractory Hematologic Malignancy\|Refractory Hodgkin Lymphoma\|Refractory T Acute Lymphoblastic Leukemia\|Systemic Mastocytosis	November 18, 2020	Phase 1
NCT03224403	Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division\|Johnson & Johnson Consumer and Personal Products Worldwide	Post-operative Dental Pain	July 19, 2017	Phase 3
NCT03154645	Grant S Lipman\|Stanford University	Acute Mountain Sickness	August 12, 2017	Phase 1
NCT00240825	Johnson & Johnson Consumer and Personal Products Worldwide\|McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.	Pain		Phase 4
NCT04730297	University of Roma La Sapienza	To Control Pain After Third Molar Surgery	January 1, 2018	Phase 4
NCT01092676	Lawson Health Research Institute	Ibuprofen\|Ankle Injuries	February 2010	Not Applicable
NCT00833365	University of Utah\|H. Lundbeck A+S	Patent Ductus Arteriosus\|Prematurity	January 2009	Not Applicable
NCT05484401	Reckitt Benckiser Healthcare (UK) Limited\|Premier Research Group plc	Tooth, Impacted\|Tooth Diseases\|Stomatognathic Diseases	August 9, 2022	Phase 3
NCT03186638	University of Rochester NCORP Research Base\|National Cancer Institute (NCI)\|University of Rochester	Cognitive Impairment\|Malignant Neoplasm	May 26, 2017	Phase 2
NCT04653506	Tel-Aviv Sourasky Medical Center	Pain	November 28, 2020	Not Applicable
NCT02076321	University of Missouri-Columbia	Fractures	January 2014	Phase 4
NCT05024825	Albany Medical College	Pain, Postoperative	August 4, 2017	Phase 4
NCT01188317	Hoffmann-La Roche	Healthy Volunteer	June 2010	Phase 1
NCT01512160	Pfizer	Post-surgical Dental Pain	October 2011	Phase 2
NCT04879823	David Chi, MD\|University of Pittsburgh	Adenotonsillectomy\|Analgesia\|Surgery	August 5, 2021	Phase 3
NCT03561558	Pharmtechnology LLC\|ClinPharmInvest, LLC	Healthy	June 11, 2018	Phase 1
NCT00644319	Oxford University Hospitals NHS Trust\|National Cancer Institute (NCI)	Metastatic Cancer	March 2007	Phase 2
NCT01373697	Laboratório Teuto Brasileiro S+A	Muscular Atrophy\|Sprains\|Tendonitis	June 2011	Phase 3
NCT04646967	Alberta Children´s Hospital	Pain, Postoperative\|Phimosis\|Paraphimosis\|Balanitis	August 20, 2022	Phase 2
NCT04037514	Máximo Vento Torres\|Instituto de Investigacion Sanitaria La Fe\|Spanish Clinical Research Network - SCReN	Patent Ductus Arteriosus After Premature Birth	July 7, 2017	Phase 3
NCT00962663	Pfizer	Healthy	August 2009	Phase 1
NCT01605903	Massachusetts Eye and Ear Infirmary\|United States Naval Medical Center, San Diego\|Brooke Army Medical Center\|United States Naval Medical Center, Portsmouth\|Madigan Army Medical Center	Tonsillectomy\|Adenoidectomy	May 3, 2012	Phase 2
NCT01771822	Pfizer	Pain	January 2013	Phase 1
NCT02069665	Liaoning University of Traditional Chinese Medicine\|Beijing University of Chinese Medicine	Pneumonia	December 2011	Not Applicable
NCT01544972	Zekai Tahir Burak Women´s Health Research and Education Hospital	Patent Ductus Arteriosus	February 2012	Phase 4
NCT02254525	Biomendi S.A.U.\|Pivotal S.L.	Postoperative Pain	May 2012	Phase 3
NCT01567072	Marius Aliuskevicius\|University of Aarhus\|Aalborg University Hospital	Forearm Fracture	April 2012	Phase 3
NCT00694369	Organon and Co	Postoperative Dental Pain	June 2008	Phase 3
NCT03783702	Stanford University\|Mayo Clinic\|Vanderbilt University Medical Center\|Albert Einstein College of Medicine\|University of British Columbia\|NorthShore University HealthSystem	Sinusitis\|Opioid Use\|Opioid Abuse\|Narcotic Use\|Otolaryngologic Disease\|Postoperative Pain\|Pain	April 4, 2019	Phase 4
NCT00000574	Vanderbilt University\|National Heart, Lung, and Blood Institute (NHLBI)	Acute Respiratory Distress Syndrome\|Lung Diseases\|Shock, Septic	September 1990	Phase 3
NCT00145730	The George Institute\|National Health and Medical Research Council, Australia\|Medical Benefits Fund Australia Pty Ltd	Osteoarthritis, Hip\|Arthroplasty, Replacement, Hip\|Arthritis, Rheumatoid	February 2002	Phase 4
NCT02507219	Laureate Institute for Brain Research, Inc.\|University of Oklahoma	Major Depressive Disorder	July 2015	Phase 2\|Phase 3
NCT00440804	Farmacon	Patent Ductus Arteriosus	December 2002	Phase 3
NCT03618823	David Chi, MD\|University of Pittsburgh	Adenotonsillectomy\|Post-operative Analgesia\|Opioid Use	October 25, 2018	Phase 1\|Phase 2
NCT03952715	University of Haifa	Healthy\|Placebo Response	April 17, 2018	Not Applicable
NCT02294019	Pfizer	Patient Compliance	November 2014	Phase 3
NCT01522326	Massachusetts General Hospital	Acute Mountain Sickness\|High Altitude Headache	March 1, 2012	Not Applicable
NCT02777320	Pamukkale University	Sciatica	March 2016	Phase 4
NCT00269191	Organon and Co	Osteoarthritis	February 5, 2003	Phase 3
NCT00470743	KK Women´s and Children´s Hospital\|National University Hospital, Singapore\|Cumberland Pharmaceuticals	Ductus Arteriosus, Patent\|Very Low Birth Weight Infants	May 2007	Phase 4
NCT02183012	Boehringer Ingelheim	Healthy	August 2002	Phase 1
NCT01938040	University of Medicine and Dentistry of New Jersey\|Rutgers, The State University of New Jersey	Gallbladder Disease	May 2013	Phase 4
NCT03554018	Montefiore Medical Center	Low Back Pain	October 16, 2018	Phase 3
NCT03385057	Massachusetts Eye and Ear Infirmary\|Emory University\|University Hospitals Cleveland Medical Center\|Madigan Army Medical Center\|United States Naval Medical Center, Portsmouth\|Rady Children´s Hospital, San Diego	Tonsillectomy With or Without Adenoidectomy	September 2018	Phase 1
NCT02519023	University of Minnesota	Acute Pain	July 2016	Phase 4
NCT00167713	Albert Schweitzer Hospital	Fever	April 2003	Phase 4
NCT05341999	Cairo University	Symptomatic Irreversible Pulpitis	April 2022	Phase 1
NCT03868137	Orlando VA Medical Center	Pelvic Pain\|IUD	September 28, 2020	Not Applicable
NCT03988075	Medstar Health Research Institute	Pain\|Thyroidectomy	July 24, 2018	Not Applicable
NCT02666846	Futura Medical Developments Ltd.\|Parexel	Pain	March 2015	Phase 1
NCT01189773	St. Justine´s Hospital	Trauma	February 2008	Phase 4
NCT03509675	University of Washington	Oral Lichen Planus\|Oral Lichenoid Mucositis\|Oral Lichenoid Reaction	April 29, 2018	Phase 2\|Phase 3
NCT02327234	University of Saskatchewan	Atopic Asthma	December 2014	Not Applicable
NCT00640809	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Bowel Diseases, Inflammatory	October 2003	Phase 4
NCT00243815	FHI 360\|Chilean Institute of Reproductive Medicine\|Ministry of Health, Chile	IUD Removal	June 2002	Phase 3
NCT02294071	Lawson Health Research Institute	Fever	December 2014	Phase 4
NCT00485160	Shaare Zedek Medical Center	Patent Ductus Arteriosus	February 2002	Phase 3
NCT05256147	Henry Ford Health System	Vitiligo	August 2015	Not Applicable
NCT03786029	Tishreen University	Local Anesthesia\|Tooth Extraction	April 1, 2019	Phase 2\|Phase 3
NCT01149564	China Medical University Hospital	Extremely Premature Infants\|PDA\|Oral Ibuprofen\|IV Ibuprofen	December 2009	Phase 1\|Phase 2
NCT00474721	University of California, San Diego	Pain	November 2002	Not Applicable
NCT02745925	Swiss Federal Institute of Technology\|University of Monterrey, Mexico	Obesity	April 2016	Not Applicable
NCT02778958	Inonu University	Bariatric Surgery Candidate\|Obesity, Morbid	January 2016	Phase 4
NCT04419948	Harokopio University\|National and Kapodistrian University of Athens\|University of Peloponnese	Diabetes Mellitus, Adult-Onset\|Platelet Dysfunction\|Postprandial Hyperglycemia\|Lipidemia\|Inflammation\|Oxidative Stress	May 16, 2019	Not Applicable
NCT04691856	Inonu University	Postoperative Pain Management	December 24, 2020	Not Applicable
NCT02605187	Stanford University	Postoperative Pain	November 2015	Not Applicable
NCT03055247	IRCCS San Raffaele\|Fondazione Telethon	Chronic Granulomatous Disease X-linked (X-CGD)	November 6, 2015	Phase 2
NCT03399318	University of Rochester\|National Institute of Neurological Disorders and Stroke (NINDS)	Malaria\|Seizures\|Coma\|Parasitemia\|Hyperpyrexia	July 2, 2018	Phase 2
NCT02320708	Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.\|Johnson & Johnson Consumer and Personal Products Worldwide	Dental Pain	December 31, 2014	Phase 2
NCT04115904	Universidad Autonoma de Baja California	Pain, Postoperative	February 8, 2018	Phase 2
NCT01149941	Dr. Reddy´s Laboratories Limited	Healthy	November 2002	Phase 1
NCT00864526	Actavis Inc.	Healthy	October 2006	Phase 1
NCT04986839	Manchester University NHS Foundation Trust	Patent Ductus Arteriosus	September 3, 2021	Phase 2\|Phase 3
NCT02781909	Fundació Institut Germans Trias i Pujol\|National Center for Tuberculosis and Lung Disease, Tbilisi, Georgia	Tuberculosis	September 2016	Phase 2
NCT00997074	Sheba Medical Center	Pain\|Pregnancy	October 2009	Phase 3
NCT03068260	Zealand University Hospital	Postoperative Pain	March 15, 2017	Phase 4
NCT01859377	Pierre Fabre Medicament	Healthy Volunteers	May 2013	Phase 1
NCT01266161	Pfizer	Pain	November 22, 2010	Phase 3
NCT02422966	Aziende Chimiche Riunite Angelini Francesco S.p.A	Ductus Arteriosus, Patent	December 2015	Phase 2
NCT00292747	Sanofi	Dysmenorrhea	May 25, 2005	Phase 4
NCT03692416	Assiut University	Vasculitis	November 11, 2018	Phase 3
NCT01334944	Cumberland Pharmaceuticals	Pain\|Fever	June 2011	Phase 4
NCT02219698	Helsinki University Central Hospital\|Vatsatautien tutkimussäätiö - foundation\|Mary and Georg Ehrnroot´s foundation\|Finnish Surgical society\|Martti I. Turunen Foundation\|Governmental competitive funds (EVO)	Diverticulitis	July 2014	Not Applicable
NCT04203771	AB Biotics, SA\|Hospital de Nens de Barcelona	Surgery--Complications\|Molar, Third	June 2016	Not Applicable
NCT04424420	Prof. Jürgen Brockmöller\|University Hospital Ulm\|University of Göttingen	Empathy	November 7, 2019	Phase 1
NCT00646906	University of Pennsylvania	Myocardial Infarction\|Arthritis	June 2, 2004	Not Applicable
NCT01536158	Zekai Tahir Burak Women´s Health Research and Education Hospital	Patent Ductus Arteriosus	February 2012	Phase 4
NCT01132222	Dr. Reddy´s Laboratories Limited	Healthy	September 2004	Phase 1
NCT05512754	University of Chicago	Elevated Serum PSA	August 1, 2022	Phase 4
NCT01334957	Cumberland Pharmaceuticals	Pain	June 2011	Phase 4
NCT02296840	Emory University	Recurrent Tonsillitis\|Obstructive Sleep Apnea\|Sleep Disordered Breathing\|Adverse Reaction to Drug	November 2014	Phase 4
NCT02571543	University Hospital Inselspital, Berne\|Merck Sharp & Dohme LLC	Ovulation\|Ovulation Inhibition\|Ovulation Inhibition+Drug Effects\|Pregnancy\|Fertilization in Vitro+Methods	January 2016	Phase 2
NCT03639571	Medherant Ltd\|Cooperative Clinical Drug Research and Development AG (CCDRD AG)	Healthy	August 9, 2018	Phase 1
NCT04476069	Princess Nourah Bint Abdulrahman University	Pain Management	January 10, 2019	Phase 3
NCT01149954	Dr. Reddy´s Laboratories Limited	Healthy	January 2003	Phase 1
NCT02603848	McMaster University\|McMaster Surgical Associates	Inguinal Surgery	February 27, 2017	Not Applicable
NCT01891084	The University of Hong Kong	Influenza	July 2013	Phase 4
NCT03476577	Norwegian University of Science and Technology\|St. Olavs Hospital\|Volvat Medisinsk Senter Stokkan\|Namsos Hospital\|Alesund Hospital	Obesity, Morbid	November 2, 2016
NCT04119739	Francisco Unda Solano\|Universidad Europea de Madrid	Carpal Tunnel Syndrome	April 14, 2020	Phase 4
NCT03003000	Boehringer Ingelheim	Back Pain\|Neck Pain	December 20, 2016	Phase 3
NCT03437707	Inonu University	Postoperative Pain Management	February 13, 2018	Not Applicable
NCT02785549	Corporacion Parc Tauli	Acute Diverticulitis	November 2016	Phase 4
NCT01077973	Pfizer	Pain	March 2010	Phase 3
NCT01230411	Thomas Jefferson University	Episodic Migraine	June 2011	Phase 4
NCT02452450	Reckitt Benckiser Healthcare (UK) Limited\|Simbec Research	Healthy Volunteer Study	January 2014	Phase 1
NCT05544734	Weill Medical College of Cornell University	Nail Diseases\|Nail Abnormality	November 2022	Phase 4
NCT02651311	Ajou University School of Medicine	Congenital Muscular Torticollis	January 16, 2016	Phase 4
NCT00217191	Maternite Regionale Universitaire\|Central Hospital, Nancy, France\|Ministere de la Sante et de la Protection Sociale, France	Premature Infants\|Patent Ductus Arteriosus	September 2004	Phase 4
NCT01377441	NYU Langone Health	Inflammatory Response	September 2011	Phase 4
NCT02482155	Aziende Chimiche Riunite Angelini Francesco S.p.A\|Cross Research S.A.	Healthy	February 2015	Phase 1
NCT01982799	University of Minnesota	Odontalgia	February 2014	Not Applicable
NCT00240864	Johnson & Johnson Consumer and Personal Products Worldwide\|McNeil Consumer & Specialty Pharmaceuticals, a Division of McNeil-PPC, Inc.	Pain		Phase 4
NCT01501747	King Faisal Specialist Hospital & Research Center	Placebo Effect\|Drug Half Life\|Pharmacokinetics	February 2012	Not Applicable
NCT01261117	Zekai Tahir Burak Women´s Health Research and Education Hospital	Patent Ductus Arteriosus	January 2009	Not Applicable
NCT02839785	University Hospital, Brest	Cerebral Palsy	March 29, 2017	Phase 3
NCT04202224	Lithuanian University of Health Sciences	Pre-emptive Analgesia in Different Psycho-emotional Status Patients	October 1, 2018	Not Applicable
NCT03482232	Universidad Miguel Hernandez de Elche\|Osasunbidea\|Servicio Madrileño de Salud, Madrid, Spain\|Fondo de Investigacion Sanitaria\|AQuAS\|Agencia de Calidad Sanitaria de Andalucía\|Ministerio de Sanidad, Servicios Sociales e Igualdad\|Servicio Aragones De Salud\|Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana\|Generalitat Valenciana\|MurciaSalud\|Osakidetza\|Castilla-La Mancha Health Service	Overdose\|Adverse Event	October 14, 2018
NCT04026464	University of Florida	Patent Ductus Arteriosus	April 2021	Phase 2
NCT03658720	Reckitt Benckiser Healthcare (UK) Limited\|Simbec Research	Healthy	December 19, 2017	Not Applicable
NCT01002573	Cumberland Pharmaceuticals	Fever	July 2010	Phase 3
NCT04630834	New York City Health and Hospitals Corporation	Pain, Acute	March 30, 2021	Phase 4
NCT03697746	Pamukkale University	Dysmenorrhea	October 1, 2018	Not Applicable
NCT00802685	University of Miami\|H. Lundbeck A+S	Patent Ductus Arteriosus	November 2007	Not Applicable
NCT01420653	AFT Pharmaceuticals, Ltd.	Dental Pain	April 2013	Phase 3
NCT01944085	KK Women´s and Children´s Hospital	Elbow Fracture	October 2008	Not Applicable
NCT01670656	Organon and Co	Dysmenorrhea	January 21, 2013	Phase 2
NCT00299039	Nova Scotia Health Authority	Pain\|Breast Diseases	May 2006	Phase 3
NCT04129437	Albert Einstein Healthcare Network	Low Back Pain	February 19, 2020	Phase 4
NCT00002276	University of Pittsburgh\|NIH AIDS Clinical Trials Information Service	HIV Infections\|Hemophilia A		Not Applicable
NCT03018015	SocraTec R&D GmbH\|SocraMetrics GmbH	Bioequivalence	September 2016	Phase 1
NCT01755702	GlaxoSmithKline	Headache, Tension-Type	July 2009	Phase 2\|Phase 3
NCT01466517	Pfizer	Healthy	November 2011	Phase 4
NCT02668783	Organon and Co	Moderate to Severe Primary Dysmenorrhea	February 11, 2016	Phase 3
NCT00864357	Actavis Inc.	Healthy	October 2006	Phase 1
NCT03111186	University of Southern California	Carpal Tunnel Syndrome\|Dupuytren Contracture\|Trigger Digit\|Ganglion Cysts\|De Quervain Disease	April 24, 2017	Phase 2
NCT01097902	Martin Angst\|Stanford University	Pain\|Inflammation	February 2010	Phase 1
NCT00631111	Wyeth is now a wholly owned subsidiary of Pfizer	Pain	November 2007	Phase 3
NCT00567528	Akron Children´s Hospital	Soft Tissue Injury	May 2006	Not Applicable
NCT03597308	Rothman Institute Orthopaedics	Post-operative Pain	March 17, 2017	Not Applicable
NCT01350596	Pfizer	Healthy	May 2011	Phase 4
NCT01053208	Dr. Reddy´s Laboratories Limited	Healthy	April 2008	Phase 1
NCT01986660	Strategic Science & Technologies, LLC	Healthy	October 2013	Phase 1
NCT01650519	Cumberland Pharmaceuticals	Arthroscopic Knee Surgery	September 2012	Phase 4
NCT04337814	Aga Khan University Hospital, Pakistan	Pain Perception	December 30, 2019	Not Applicable
NCT03404518	Loma Linda University	Outpatient Surgery\|Pain, Postoperative	February 21, 2018	Phase 3
NCT01200069	Rutgers, The State University of New Jersey	Depression, Myalgia	July 2010	Phase 4
NCT03858231	Sanford Health	Knee Injuries\|Pain, Postoperative\|Opioid Use	October 29, 2018	Phase 4
NCT03859024	University of Alabama at Birmingham	Pain, Postoperative\|Urethral Stricture	March 22, 2019	Phase 4
NCT03437460	University of Pennsylvania\|Institute for Financial Management and Research	Pain, Chronic	May 10, 2017	Not Applicable
NCT02815189	Universidad Autonoma de Baja California	Pain	February 2014	Phase 2
NCT01035346	Pfizer	Infection	January 2010	Phase 3
NCT02417337	University of Khartoum	Pain\|Postoperative Pain\|Irreversible Pulpitis	August 2012	Phase 2
NCT03824119	University of Southern California	Preeclampsia\|Gestational Hypertension\|Superimposed Preeclampsia\|Chronic Hypertension in Obstetric Context	December 11, 2018	Phase 4
NCT03008876	Albany Medical College	Patent Ductus Arteriosus	January 1, 2017	Not Applicable
NCT02476422	Novartis Pharmaceuticals\|Novartis	Post Operative Dental Pain	April 2015	Phase 3
NCT03619785	Andrew A Herring\|Oregon Health and Science University\|University of California, Los Angeles\|Alameda Health System	Rib Fractures\|Rib Fracture Multiple	November 6, 2018	Phase 4
NCT02915055	NYU Langone Health	Multimodal Analgesia\|Nonsteroidal Anti-inflammatory Drugs	September 1, 2016
NCT01511887	Hormozgan University of Medical Sciences	Patent Ductus Arteriosus	January 2011	Not Applicable
NCT01488955	Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH\|University Medical Center Goettingen	Urinary Tract Infection	February 2012	Phase 4
NCT00450216	Horizon Pharma Ireland, Ltd., Dublin Ireland	Ulcer	March 2007	Phase 3
NCT01559259	Pfizer	Pain	April 10, 2012	Phase 2
NCT02480114	Vanderbilt-Ingram Cancer Center\|National Cancer Institute (NCI)	Malignant Head and Neck Neoplasm\|Mucositis\|Radiation-Induced Disorder	July 2015	Phase 3
NCT02432456	Medical College of Wisconsin	Wounds and Injuries\|Rib Fractures	September 2015	Phase 4
NCT01901393	Cumberland Pharmaceuticals	Pain	July 2013	Phase 4
NCT00484744	University of Missouri, Kansas City	Orthodontic Pain	June 2007	Phase 4
NCT00921505	Ullevaal University Hospital\|University of Oslo\|Oslo University Hospital	Pain	May 2009	Phase 4
NCT01786200	NHS Greater Glasgow and Clyde\|Academy of Medical Sciences\|Wellcome Trust	Colon Cancer	February 2013	Not Applicable
NCT04334629	King´s College London\|Guy´s & St Thomas NHS Foundation Trust	Coronavirus\|Respiratory Distress Syndrome\|SARS-CoV Infection	May 26, 2020	Phase 4
NCT01131000	Cumberland Pharmaceuticals	Fever	June 2002	Phase 3
NCT04772781	Apsen Farmaceutica S.A.	Low Back Pain, Mechanical\|Low Back Pain\|Acute Low Back Pain	May 2022	Phase 2
NCT01563289	Orion Corporation, Orion Pharma	Pain	February 2012	Phase 3
NCT00121563	National Institute of Nursing Research (NINR)\|National Institutes of Health Clinical Center (CC)	Pain	July 2005	Phase 2
NCT00046358	National Institute of Mental Health (NIMH)\|National Institutes of Health Clinical Center (CC)	Alzheimer Disease	September 2002	Phase 4
NCT01464983	Bayer	Headache\|Tension-Type Headache\|Tension-Type Headache (Episodic)	January 2004	Phase 4
NCT00565500	University of Chieti\|Pfizer\|G. d´Annunzio University	Ischemic Heart Disease\|Osteoarthritis	April 2003	Phase 4
NCT01755728	Hillel Yaffe Medical Center	PDA	January 1, 2013	Phase 3
NCT04372264	Pamukkale University	Headache, Migraine	October 15, 2018	Phase 4
NCT03771755	Indonesia University	Lower Extremity Problem\|Surgery\|Postoperative Pain	July 1, 2017	Not Applicable
NCT00150280	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Pain, Postoperative	October 2004	Phase 3
NCT04726085	Woman´s	Preterm Labor	February 1, 2021	Not Applicable
NCT00450658	Horizon Pharma Ireland, Ltd., Dublin Ireland	Peptic Ulcer	March 2007	Phase 3
NCT00462722	University of Colorado, Denver\|National Institute on Aging (NIA)	Aging\|Physical Fitness	July 2007	Not Applicable
NCT01400737	Zekai Tahir Burak Women´s Health Research and Education Hospital	Oral Ibuprofen Prophylaxis in Very Low Birth Weight Infants	July 2011	Not Applicable
NCT02985177	St. Justine´s Hospital	Emergency Service, Hospital\|Child+Adolescent Problem\|Acute Pain\|Fentanyl\|Ibuprofen\|Analgesics, Opioid\|Anti-inflammatory Agents, Non-steroidal	December 2019	Phase 4
NCT04133623	IRCCS Burlo Garofolo	Acute Pain Due to Trauma	November 19, 2019	Phase 3
NCT01842633	GlaxoSmithKline	Pain	April 1, 2013	Phase 3
NCT02963701	Boehringer Ingelheim	Healthy Volunteers	December 20, 2016	Phase 1
NCT04321655	Asir John Samuel\|Maharishi Markendeswar University (Deemed to be University)	Knee Osteoarthritis	April 1, 2022	Not Applicable
NCT00258791	Norwegian University of Science and Technology	Mental Disorders	January 2012	Not Applicable
NCT04397913	Shandong University\|West China Second University Hospital	Patent Ductus Arteriosus	May 25, 2020
NCT02863614	University of Sao Paulo	Subfertility\|Infertility	May 2015	Not Applicable
NCT00624871	Al-Azhar University	Hypoxic Ischemic Encephalopathy\|Perinatal Asphyxia	April 2004	Not Applicable
NCT01216163	Pfizer	Pain	October 2010	Phase 3
NCT03088800	Antonios Likourezos\|Maimonides Medical Center	Pain Management	April 30, 2018	Phase 2
NCT01593163	Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz	Patent Ductus Arteriosus	May 2009	Phase 3
NCT03523988	University of Washington	NSAID\|Pain Management	May 2, 2017	Phase 4
NCT00855777	Universita di Verona	Dental Extraction	April 2009	Phase 4
NCT02521207	Oxford Pharmascience Ltd\|Quotient Clinical	Gastroduodenal Erosions	July 2015	Phase 1
NCT01104844	AFT Pharmaceuticals, Ltd.	Dental Pain		Phase 2
NCT02183051	Boehringer Ingelheim	Pain	April 1998	Phase 2
NCT03545893	University of Pennsylvania	Abortion Second Trimester	June 19, 2018	Phase 4
NCT04123717	Hamad Medical Corporation	Fever	October 11, 2019	Early Phase 1
NCT01929031	Boehringer Ingelheim	Pain, Postoperative\|Tooth Diseases	August 2013	Phase 3
NCT01879371	Boehringer Ingelheim	Healthy	June 2013	Phase 1
NCT00729976	Assaf-Harofeh Medical Center	Fever	September 2008	Phase 4
NCT02761980	Pfizer	Fever	December 6, 2016	Phase 3
NCT00630929	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	Osteoarthritis, Knee	January 2003	Phase 4
NCT02007434	Kythera Biopharmaceuticals	Moderate or Severe Submental Fullness	December 2013	Phase 3
NCT02629354	Boehringer Ingelheim	Healthy	November 2015	Phase 1
NCT00890604	University of Washington\|Gaymar Industries, Inc.	Subarachnoid Hemorrhage\|Severe Traumatic Brain Injury	July 2009	Not Applicable
NCT00631514	University Hospital of Split\|Dr Ivancica Pavlicevic Family Practice Office	Hypertension	January 2005	Phase 4
NCT00600405	MaineHealth\|Maine Medical Center Mentored Research Committee	Nephrolithiasis\|Ureteral Calculi	August 2006	Not Applicable
NCT05374057	University Hospital, Akershus\|University of Oslo\|The Dam Foundation	Acute Neck Pain	May 23, 2022	Phase 4
NCT00372801	GlaxoSmithKline	Osteoarthritis	August 2005	Phase 1
NCT01118273	Bayer	Sleep	January 2008	Phase 4
NCT00411190	GlaxoSmithKline	Osteoarthritis	October 19, 2006	Phase 1
NCT03893175	University of Pennsylvania	Impacted Third Molar Tooth\|Pain, Acute	May 10, 2019	Phase 1
NCT01822665	GlaxoSmithKline	Gastrointestinal Mucosal Damage	February 2012	Phase 4
NCT04905563	Le Bonheur Children´s Hospital\|The Campbell Foundation	Supracondylar Humerus Fracture	June 7, 2021	Phase 4
NCT02140970	University of Colorado, Denver\|Children´s Hospital Colorado	Disorder of Urinary Stent\|Ureteral Spasm\|Ureteropelvic Junction Obstruction\|Urolithiasis	May 2014	Not Applicable
NCT04941443	Boston Medical Center	Pain\|Medical Abortion	October 4, 2021	Phase 4
NCT03404206	Bayer	Pain, Postoperative	February 12, 2018	Phase 4
NCT03907176	Heron Therapeutics	Analgesia	April 5, 2019	Phase 3
NCT04551196	Washington University School of Medicine	Pain, Postoperative\|Tonsillar Hypertrophy\|Tonsillitis	September 28, 2020	Phase 3
NCT03860428	Lviv National Medical University	Patent Ductus Arteriosus	February 15, 2019	Not Applicable
NCT01827475	Stony Brook University	Pain	July 2010	Phase 2
NCT03974932	Heron Therapeutics	Analgesia	June 5, 2019	Phase 3
NCT05548582	Johns Hopkins University	Pain, Postoperative\|Opioid Misuse\|Opioid Use\|Pain	December 2022	Not Applicable
NCT05329454	Overseas Pharmaceuticals, Ltd.	Chronic Pain	December 24, 2020	Phase 1
NCT04866355	University of Alcala	Women With Primary Dysmenorrhea	February 28, 2021	Not Applicable
NCT01170637	Boehringer Ingelheim	Healthy	July 2010	Phase 1
NCT00758836	Merck Sharp & Dohme LLC	Migraine	December 3, 2008	Phase 2
NCT01392378	Pfizer	Pneumococcal Vaccines	August 2011	Phase 4
NCT05493540	Nada Youssef\|Ain Shams University	Patent Ductus Arteriosus After Premature Birth\|Patent Ductus Arteriosus Conservative Management	April 15, 2021	Phase 2
NCT02850211	Seoul National University Bundang Hospital	Rotator Cuff Tear	September 2011	Phase 4
NCT03722238	Pfizer	Pain	December 27, 2018	Phase 3
NCT01606527	Naval Health Research Center\|University of California, San Diego	Spectrum of Altitude-associated Neurologic Forms of Altitude	July 2012	Phase 2
NCT02538237	Islamic Azad University, Tehran	Periodontitis	November 2013	Phase 2\|Phase 3
NCT05109312	Heron Therapeutics	Analgesia	October 18, 2021	Phase 4
NCT03068897	Montefiore Medical Center	Low Back Pain	May 3, 2017	Phase 4
NCT01785108	Johnny Ludvigsson\|Swedish Child Diabetes Foundation\|The Research Council of South East Sweden (FORSS)\|Diamyd Medical AB\|Linkoeping University	Diabetes Mellitus, Type 1	February 2013	Phase 2
NCT01686802	Lawson Health Research Institute	Post-operative Pain	September 2012	Phase 2
NCT03241030	University of Texas at Austin	Herpangina\|Gingivostomatitis\|Hand, Foot and Mouth Disease	September 12, 2017	Phase 2
NCT02182960	Boehringer Ingelheim	Healthy	September 1998	Phase 1
NCT01098747	Pfizer	Pain	April 2010	Phase 3
NCT00225732	Cumberland Pharmaceuticals	Pain	January 2005	Phase 3
NCT00880373	London North West Healthcare NHS Trust\|Medical Research Council CTU	Sickle Cell Disease	March 2011	Phase 4
NCT01973010	Chengdu University of Traditional Chinese Medicine	Low Back Pain	June 2013	Phase 2\|Phase 3
NCT02735122	Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division\|Johnson & Johnson Consumer and Personal Products Worldwide	Post Operative Dental Pain	April 30, 2016	Phase 3
NCT02050958	Oxford Pharmascience Ltd	NSAID Related Gastric Irritation	February 2014	Phase 1
NCT02477007	Assistance Publique - Hôpitaux de Paris	Pain\|Long-bone Fractures	December 3, 2015	Phase 3
NCT01070745	Shaare Zedek Medical Center	Patent Ductus Arteriosus	June 2010	Phase 2
NCT01066676	Gebro Pharma GmbH	Osteoarthritis of the Hip or Knee	October 2009	Phase 4
NCT05509244	The Catholic University of Korea	Gynecologic Disease	September 9, 2022	Not Applicable
NCT04533568	Kecioren Education and Training Hospital	Migraine Without Aura	September 1, 2020	Phase 4
NCT00921830	Johnson & Johnson Consumer and Personal Products Worldwide	Healthy	April 2004	Phase 1
NCT00790270	Stony Brook University	Cervical Strain	January 2003	Phase 2
NCT03375593	Lawson Health Research Institute\|Canadian Institutes of Health Research (CIHR)	Distal Radius Fracture\|Pain Management\|Metacarpal Fracture	August 1, 2019	Phase 4
NCT03103022	University of Florida	Patent Ductus Arteriosus\|Neonate	June 12, 2017	Phase 1
NCT05011149	IWK Health Centre\|BC Children´s Hospital Research Institute\|CHU de Quebec-Universite Laval\|Sunnybrook Health Sciences Centre\|Mount Sinai Hospital, Canada\|Sharp Mary Birch Hospital for Women & Newborns\|Canadian Institutes of Health Research (CIHR)\|Dalhousie Medical Research Foundation\|Children´s Hospital of Orange County, OC, California, United States\|University of Alberta	Patent Ductus Arteriosus After Premature Birth	January 10, 2022	Phase 3
NCT02327338	Future Sciene Technology\|Pfizer	Heat\|Pain	November 2014	Phase 4
NCT01932554	St. Louis University\|Janssen Services, LLC	Sickle Cell Disease\|Hb-SS Disease With Vasoocclusive Pain\|Hemoglobin SS Disease With Vasoocclusive Crisis\|Other Sickle Cell Disease With Vaso-Occlusive Pain\|Hemoglobin SS Disease With Crisis	November 2013	Phase 2
NCT01756209	University of Catanzaro	Migraine	January 2010	Phase 4
NCT03571737	East Carolina University	Acute Musculoskeletal Disease\|Sprains\|Sprains and Strains\|Injuries\|Emergencies\|Trauma\|Acute Pain	June 23, 2018	Phase 3
NCT03184649	Cairo University	Analgesic Drugs\|Pain Relief	May 1, 2017	Phase 1\|Phase 2
NCT00568217	University of Oulu	Recurrence of Febrile Seizure	September 1997	Phase 4
NCT03959969	Medstar Health Research Institute	Opioid Use, Unspecified	July 17, 2019	Not Applicable
NCT05512013	United States Army Research Institute of Environmental Medicine	Bone Resorption\|Stress Fracture\|Bone Injury	February 15, 2022	Phase 1
NCT02268955	Valleywise Health	Biliary Colic	September 9, 2014	Not Applicable
NCT01307020	Menarini Group\|PRA Health Sciences	Pain	February 2011	Phase 2
NCT02763059	King Abdulaziz University	Pain Measurement	September 2013	Phase 4
NCT01330459	Elizabeth Micks\|Planned Parenthood Federation of America\|Oregon Health and Science University	Pain	February 2011	Phase 4
NCT05248152	University Medical Centre Ljubljana	Postoperative Pain	January 13, 2022	Not Applicable
NCT02521415	Wake Forest University Health Sciences\|Carolinas Trauma Network Research Group\|Charlotte, Houston, Milwaukee Prehospital Emergency Research Nodal Center-CHaMP-ERNC	Bone Fracture	December 2015	Phase 2
NCT01362491	Pfizer	Pain	June 2011	Phase 3
NCT04485403	Poznan University of Medical Sciences	PCOS\|Hyperandrogenism\|Inflammation	September 1, 2019	Phase 2
NCT05097768	Alfarabi Colleges	Symptomatic Irreversible Pulpitis	August 15, 2021	Not Applicable
NCT02588027	University of California, San Francisco	Rotator Cuff Tear Arthropathy	October 2015	Not Applicable
NCT00520442	Medical College of Wisconsin\|Children´s Hospital and Health System Foundation, Wisconsin	Fracture	September 2003	Not Applicable
NCT01238120	University of Rochester\|National Institutes of Health (NIH)\|National Cancer Institute (NCI)	Cancer-related Cognitive Difficulties	November 2010	Phase 2
NCT01172405	Mantecorp Industria Quimica e Farmaceutica Ltd.	Headache	October 2010	Phase 3
NCT01053338	Dr. Reddy´s Laboratories Limited	Healthy	April 2008	Phase 1
NCT02233582	University of California, San Francisco	High Altitude	September 2014	Phase 1
NCT04414995	Indonesia University	Analgesia	June 5, 2020	Phase 2\|Phase 3
NCT00004440	FDA Office of Orphan Products Development\|Case Western Reserve University	Cystic Fibrosis	August 1996	Not Applicable
NCT00961753	OSF Healthcare System	Patent Ductus Arteriosus	August 2009	Phase 4
NCT02686021	University Hospital, Basel, Switzerland	Pain, Postoperative	February 15, 2016	Phase 4
NCT01028079	Bayer	Low Back Pain	November 2005	Phase 3
NCT02268058	McMaster Children´s Hospital	Concussion\|Headache	October 2013	Not Applicable
NCT02884219	Radboud University Medical Center\|ZonMw: The Netherlands Organisation for Health Research and Development	Patent Ductus Arteriosus	December 23, 2016	Not Applicable
NCT03955211	Heron Therapeutics	Analgesia	June 24, 2019	Phase 2
NCT02243254	Seoul National University Hospital	Ibuprofen\|Remifentanil\|Hyperalgesia\|Pain, Postoperative	July 2014	Not Applicable
NCT01886196	University of Saskatchewan\|Canadian Institutes of Health Research (CIHR)	Sarcopenia\|Osteoporosis	April 2013	Not Applicable
NCT02911701	University of New Mexico	Pre-Eclampsia\|HELLP Syndrome\|Eclampsia	September 2016	Phase 4
NCT02212990	Duke University\|Centers for Disease Control and Prevention	Fever	September 2014	Not Applicable
NCT02912650	Pfizer	Post-surgical Pain Following Extraction of Molar Teeth	September 2015	Phase 3
NCT00921700	Ullevaal University Hospital\|University of Oslo\|Oslo University Hospital	Pain, Postoperative	June 2009	Phase 4
NCT03767933	University of Alberta\|University of Manitoba\|Centre hospitalier de l´Université de Montréal (CHUM)\|University of Western Ontario, Canada\|University of Calgary\|The Hospital for Sick Children\|University of Ottawa	Musculoskeletal Injury	April 20, 2019	Phase 2
NCT03184766	Reckitt Benckiser Healthcare (UK) Limited\|Simbec Research	Healthy	August 10, 2016	Phase 1
NCT02358707	Cukurova University	Osteoarthritis, Knee	May 2014	Not Applicable
NCT03952650	National Institute of Allergy and Infectious Diseases (NIAID)\|National Institutes of Health Clinical Center (CC)	Malaria	May 23, 2019	Phase 1\|Phase 2
NCT03588910	Montefiore Medical Center	Surgery	August 8, 2018	Phase 2
NCT02086097	Daniel Chavarría Bolaños\|Universidad Autonoma de San Luis Potosí	Irreversible Pulpitis	August 2013	Phase 4
NCT00111046	Royal Liverpool University Hospital	Choroidal Melanoma\|Melanoma\|Eye Neoplasms	February 2001	Phase 1\|Phase 2
NCT03016650	Muharrem Ucar\|Inonu University	Analgesia\|Percutaneous Nephrolithotomy	January 2017	Phase 4
NCT02441530	Bezmialem Vakif University\|Seda Ates\|Osman Sevket\|Mucize Ozdemir\|Gulsah Ilhan\|Yildirim, Zeynep Baysal, M.D.	Primary Dysmenorrhoea	November 2012	Phase 3
NCT03978767	Washington University School of Medicine	Preeclampsia Severe\|Preeclampsia Postpartum	June 10, 2019	Phase 2
NCT05610384	Cairo University	Postoperative Pain\|Hysterectomy	November 2022	Not Applicable
NCT04102566	Benaroya Research Institute\|Virginia Mason Hospital+Medical Center	Pain\|BPH With Urinary Obstruction\|BPH With Urinary Obstruction With Other Lower Urinary Tract Symptoms	December 8, 2017	Phase 4
NCT04157036	Walter Reed National Military Medical Center	Irreversible Pulpitis	February 1, 2020	Phase 3
NCT01529346	Pfizer	Postoperative Dental Pain	December 12, 2011	Phase 2
NCT00993863	Cubist Pharmaceuticals LLC	Acute Pain	June 2007	Phase 2
NCT05428293	Laboratorios Silanes S.A. de C.V.	Healthy	February 22, 2019	Phase 1
NCT00812422	Inje University	Fever\|Respiratory Tract Infection	February 2008	Phase 3
NCT04881474	Dr. Lutfi Kirdar Kartal Training and Research Hospital	Analgesia; Ibuprofen; Acetaminophen; Oxidative Stress	January 2, 2020	Not Applicable
NCT03785756	Reckitt Benckiser Healthcare (UK) Limited\|Premier Research Group plc	Pain	April 29, 2019	Phase 3
NCT03880981	University of California, Los Angeles	Musculoskeletal Injury	August 1, 2019	Not Applicable
NCT03584152	Stanford University	Pain, Postoperative	August 9, 2019	Phase 2
NCT03872843	Wake Forest University Health Sciences	Kidney Stone	September 19, 2019	Phase 4
NCT02344225	State University of New York - Downstate Medical Center\|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)\|Food and Drug Administration (FDA)	Retinopathy of Prematurity	January 1, 2015	Phase 2
NCT01860833	University of Catanzaro	Knee Osteoarthritis	April 2010	Phase 4
NCT00833157	Bispebjerg Hospital\|Lund University\|The Danish Rheumatism Association\|Ministry of the Interior and Health, Denmark	Osteoarthritis of the Knee	February 2005	Phase 1
NCT04087317	Rambam Health Care Campus	Pain\|Post Partum Depression\|Opioid Use\|Breast Feeding	September 1, 2019	Not Applicable
NCT03631433	Ohio State University	Pain, Postoperative	February 10, 2016	Phase 4
NCT00740857	Wyeth is now a wholly owned subsidiary of Pfizer	Pain	August 2008	Phase 4
NCT00115336	Children´s Hospital Medical Center, Cincinnati\|National Heart, Lung, and Blood Institute (NHLBI)\|University of Texas Southwestern Medical Center	Hematologic Diseases\|Anemia, Sickle Cell	January 2005	Phase 4
NCT03953729	University of Sao Paulo	Pain\|Anxiety	April 1, 2019	Early Phase 1
NCT04320914	Maharishi Markendeswar University (Deemed to be University)\|Himachal Pradesh Council for Science Technology and Environment (HIMCOSTE)	Osteo Arthritis Knee	September 28, 2020	Not Applicable
NCT02241512	University of Texas Southwestern Medical Center	Post-ERCP Acute Pancreatitis	September 2014	Phase 2
NCT05076110	Mayo Clinic	Hip Arthroscopy	April 7, 2022	Phase 4
NCT01243996	University of Florence	Ductus Arteriosus, Patent	June 2008	Phase 2\|Phase 3
NCT04767178	Istanbul Medeniyet University	Retinopathy of Prematurity\|Pain Management	January 1, 2020
NCT00913627	Pfizer	Pain	May 7, 2009	Phase 2
NCT00346216	Pfizer´s Upjohn has merged with Mylan to form Viatris Inc.\|The Cleveland Clinic\|Pfizer	Arthritis, Rheumatoid	October 4, 2006	Phase 4
NCT02902302	Aziende Chimiche Riunite Angelini Francesco S.p.A\|Cross Research S.A.	Healthy	May 2016	Phase 1
NCT01514175	Culpeper Surgery Center\|Cumberland Pharmaceuticals	Chronic Pelvic Pain	January 2012	Phase 4
NCT02902289	Aziende Chimiche Riunite Angelini Francesco S.p.A\|Cross Research S.A.	Healthy	June 2016	Phase 1
NCT03497715	Reckitt Benckiser Healthcare (UK) Limited	Healthy Subjects	April 14, 2015	Phase 1
NCT01900795	Purdue Pharma LP	Postsurgical Pain Due to Third Molar Extraction	July 2013	Phase 2
NCT04232072	Medipol University	Obesity	February 11, 2020	Not Applicable
NCT00763997	Ruhr University of Bochum\|Pfizer	Platelet Aggregation	February 2004	Not Applicable
NCT03441269	Antonios Likourezos\|Maimonides Medical Center	Pain, Acute	November 1, 2018	Phase 4
NCT04358497	Hospital de Clínicas Dr. Manuel Quintela\|University of the Republic, Uruguay\|Centro Cardiovascular Universitario\|Centro Hospitalario Pereyra Rossell	Pelvic Congestive Syndrome\|Pelvic Varices\|Venous Disease	October 1, 2020	Phase 4
NCT02288923	Royal Devon and Exeter NHS Foundation Trust	Arthritis Knee	March 2015	Not Applicable
NCT05013567	Brainfarma Industria Química e Farmacêutica S+A	Musculoskeletal Pain\|Acute Pain\|Stretch\|Sprains	August 2022	Phase 3
NCT02096913	Jan M. Schwab, MD, PhD\|Else Kröner Fresenius Foundation\|Charite University, Berlin, Germany	Spinal Cord Injury	June 2013	Phase 1
NCT03228992	Jean Brown Research	Muscle Soreness	April 10, 2017	Phase 4
NCT01429935	Qazvin University Of Medical Sciences	Impacted Third Molar Tooth	June 2010	Phase 2
NCT03701074	University of South Alabama	Patent Ductus Arteriosus\|Preterm Infant\|Bronchopulmonary Dysplasia	December 15, 2018	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : ≥ 100 mg/mL ( 438.10 mM )

DMSO : 20.83 mg/mL ( 91.26 mM ; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.3810 mL	21.9048 mL	43.8097 mL
5 mM	0.8762 mL	4.3810 mL	8.7619 mL
10 mM	0.4381 mL	2.1905 mL	4.3810 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, sodium salt (1:1)

Hydratropic acid, p-isobutyl-, sodium salt

Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-, sodium salt

Sodium ibuprofen

2-(4-Isobutylphenyl)propionic acid sodium salt

Ibuprofen sodium salt

Ibuprofen sodium

Sodium 2-(4-isobutylphenyl)propionate

α-Methyl-4-(2-methylpropyl)benzeneacetic acid sodium salt