[CAS NO. 314-13-6] Evans Blue

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PRODUCTS SPECIFICATIONS [314-13-6]

Catalog

HY-B1102

Brand

MCE

CAS

314-13-6

DESCRIPTION [314-13-6]

Overview

MDL	MFCD00004021
Molecular Weight	960.81
Molecular Formula	C34H24N6Na4O14S4
SMILES	CC1=CC(C2=CC=C(/N=N/C3=C(O)C4=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C4C=C3)C(C)=C2)=CC=C1/N=N/C5=C(O)C6=C(N)C(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C6C=C5

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively). IC50 value: 220/150 nM Target: L-glutamate uptake receptor Evans blue is a biological dye, for detection of cell survival. Evans Blue can not penetrate healthy cell membrane, but can penetrate into death cell. Binds with high affinity to serum albumin.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05140083	First Affiliated Hospital of Fujian Medical University	Positron-Emission Tomography	April 20, 2021	Phase 1

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H ₂ O : 33.33 mg/mL ( 34.69 mM ; Need ultrasonic)

DMSO : ≥ 25 mg/mL ( 26.02 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0408 mL	5.2039 mL	10.4079 mL
5 mM	0.2082 mL	1.0408 mL	2.0816 mL
10 mM	0.1041 mL	0.5204 mL	1.0408 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (2.60 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: 2.5 mg/mL (2.60 mM); Clear solution; Need warming

* All of the co-solvents are available by MCE.

Synonyms

1,3-Naphthalenedisulfonic acid, 6,6′-[(3,3′-dimethyl[1,1′-biphenyl]-4,4′-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-, sodium salt (1:4)

Azovan Blue

C.I. Direct Blue 53, tetrasodium salt

1,3-Naphthalenedisulfonic acid, 6,6′-[(3,3′-dimethyl[1,1′-biphenyl]-4,4′-diyl)bis(azo)]bis[4-amino-5-hydroxy-, tetrasodium salt

T 1824

C.I. 23860

4,4′-Bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3′-bitolyl tetrasodium salt

Diazol Pure Blue BF

Evans Blue

C.I. Direct Blue 53

Direct Blue 53

Evan's Blue