[CAS NO. 314245-33-5] IU1
PRODUCTS SPECIFICATIONS [314245-33-5]
DESCRIPTION [314245-33-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 300.37 |
| Molecular Formula | C18H21FN2O |
| SMILES | CC1=CC(C(CN2CCCC2)=O)=C(C)N1C3=CC=C(F)C=C3 |
6 Publications Citing Use of MCE
Summary
IU1 is a special Usp14 inhibitor with an IC 50 of 4-5 μM.
IC50 & Target
IC50: 4-5 μM (Usp14) [1]
In Vitro
Usp14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of ubiquitin-protein conjugates, in vivo and in vitro. IU1inhibits the catalytic activity of proteasome associated Usp14 in vitro. The IC 50 of IU1 for Usp14 is 4-5 μM. IU1 binds specifically to the activated form of Usp14. IU1 can potentially inhibit Usp14 by preventing its docking on the proteasome, but direct tests of this scenario proved negative. Usp14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 also promotes degradation of Sic1, a CDK inhibitor from S. cerevisiae [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 41.67 mg/mL ( 138.73 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.3292 mL | 16.6461 mL | 33.2923 mL |
| 5 mM | 0.6658 mL | 3.3292 mL | 6.6585 mL |
| 10 mM | 0.3329 mL | 1.6646 mL | 3.3292 mL |