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[CAS NO. 327-57-1] L-Norleucine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-Y0017 |
| Brand: | MCE |
| CAS: | 327-57-1 |
Overview
| MDL | MFCD00064423 |
|---|---|
| Molecular Weight | 131.17 |
| Molecular Formula | C6H13NO2 |
| SMILES | N[C@@H](CCCC)C(O)=O |
Summary
L-Norleucine ((S)-2-Aminohexanoic acid) is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity.
IC50 & Target
|
Human Endogenous Metabolite
|
In Vitro
L-Norleucine is an isomer of leucine, specifically affecting protein synthesis in skeletal muscle [1] . L-Norleucine has antiviral activity. L-Norleucine interacts with hnRNPA2/B1 protein to suppresses the expressions of Twist1 and Snail, two inhibitors of E-cadherin, and promotes the expression of E-cadherin, resulting in the inhibition of tumor metastasis [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT00081952 | National Center for Complementary and Integrative Health (NCCIH) |
Hot Flashes
|
October 2003 | Phase 1|Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 10 mg/mL ( 76.24 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 7.6237 mL | 38.1185 mL | 76.2369 mL |
| 5 mM | 1.5247 mL | 7.6237 mL | 15.2474 mL |
| 10 mM | 0.7624 mL | 3.8118 mL | 7.6237 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 2.86 mg/mL (21.80 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
References
- [1] Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37.
- [2] He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20.
Synonyms
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