[CAS NO. 329691-12-5] FPR-A14
PRODUCTS SPECIFICATIONS [329691-12-5]
DESCRIPTION [329691-12-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 404.42 |
| Molecular Formula | C23H20N2O5 |
| SMILES | O=C(C1=CC=C(OCO2)C2=C1)N/N=C/C3=CC=C(OCC4=CC=CC=C4)C(OC)=C3 |
Summary
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca 2+ mobilization and chemotaxis with EC 50 s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation [1] [2] .
In Vitro
FPR-A14 (compound 14) activates Ca
2+
release with an EC
50
of 630 nM in human neutrophils. FPR-A14 is a neutrophil chemoattractant and dose-dependently induces neutrophil migration with an EC
50
value of 42 nM
[1]
.
FPR-A14 (1-10 μM; 48h) elicites a significant increase in % cell differentiation versus controls at concentrations of 4μM (32.0%), 6μM (64.9%), 8μM (89.1%) and 10μM (93.3%) in mouse neuroblastoma N2a cells. FPRa14 (100μM) produces similar effects in IMR-32 and SH-SY5Y cells
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
References
- [1] Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74.
- [2] Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815.