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[CAS NO. 33889-69-9] Silychristin
| Ships within | Stock | Price | Qty | Total |
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| Catalog: | HY-N0647 |
| Brand: | MCE |
| CAS: | 33889-69-9 |
Overview
| MDL | MFCD00883715 |
|---|---|
| Molecular Weight | 482.44 |
| Molecular Formula | C25H22O10 |
| SMILES | O=C1[C@H](O)[C@@H](C2=CC(O)=C(O[C@@H](C3=CC=C(O)C(OC)=C3)[C@@H]4CO)C4=C2)OC5=CC(O)=CC(O)=C15 |
Summary
IC50 & Target
MCT8 [2]
In Vitro
Silychristin exhibits a strong inhibition of MCT8-mediated T3 uptake with an IC
50
of 110 nM in MCT8 overexpressing MDCK1-cells
[2]
.
Silychristin causes no cytotoxic for fibroblasts
[3]
.
Silychristin (6.5-75 μM; 24 hours) diminishes UVA toxicity and reduces ROS generation, and the protective effect is dose-dependent
[3]
.
Silychristin (12.5μM, 25μM) reduces the metalloproteinase-1 (MMP-1) level in cells
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [3]
| Cell Line: | NHDF |
| Concentration: | 6.5 μM,12.5 μM,25 μM,50 μM,75 μM |
| Incubation Time: | 24 hours |
| Result: | Diminished UVA toxicity and reduced ROS generation in dose-dependent. |
Cell Viability Assay [3]
| Cell Line: | NHDF |
| Concentration: | 12.5 μM, 25 μM |
| Incubation Time: | |
| Result: | Reduced the metalloproteinase-1 (MMP-1) level in cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 207.28 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0728 mL | 10.3640 mL | 20.7280 mL |
| 5 mM | 0.4146 mL | 2.0728 mL | 4.1456 mL |
| 10 mM | 0.2073 mL | 1.0364 mL | 2.0728 mL |
References
- [1] Biedermann D, et al. Silychristin: Skeletal Alterations and Biological Activities. J Nat Prod. 2016 Dec 23;79(12):3086-3092.
- [2] Johannes J, et al. Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8. Endocrinology. 2016 Apr;157(4):1694-701.
- [3] Rajnochová Svobodová A, et al. A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts. Arch Dermatol Res. 2019 Aug;311(6):477-490.
Synonyms
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