[CAS NO. 338967-87-6] Mdivi-1

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Catalog:	HY-15886
Brand:	MCE
CAS:	338967-87-6

Overview

MDL	MFCD00974506
Molecular Weight	353.22
Molecular Formula	C15H10Cl2N2O2S
SMILES	O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3

For research use only. We do not sell to patients.

85 Publications Citing Use of MCE

[1]J Pineal Res. 2018 Sep;65(2):e12491.
[2]J Pineal Res. 2018 Jan;64(1).
[3]Nat Commun. 2022 Jul 6;13(1):3882.
[4]Basic Res Cardiol. 2021 Dec 16;116(1):65.
[5]Cell Death Differ. 2022 Jun 22.
[6]Redox Biol. 2022 Feb;49:102216.
[7]Redox Biol. 2020 Jul;34:101523.
[8]Autophagy. 2021 Nov;17(11):3592-3606.
[9]Autophagy. 2020 Aug;16(8):1413-1435.
[10]J Hazard Mater. 15 February 2022, 127268.
[11]Environ Health Perspect. 2022 May;130(5):57004.
[12]Theranostics. 2021 Jan 1;11(2):522-539.
[13]Theranostics. 2019 Feb 28;9(6):1698-1713.
[14]Cell Mol Immunol. 2022 Jan;19(1):67-78.
[15]Cell Rep. 2022 Apr 12;39(2):110635.
[16]Gut Microbes. Jan-Dec 2022;14(1):2096989.
[17]Environ Int. 2020 Dec 18;147:106319.
[18]Carbohydr Polym. 8 July 2022, 119841.
[19]Cell Death Dis. 2019 Mar 8;10(3):232.
[20]Cell Death Dis. 2018 Sep 5;9(9):907.
[21]Cell Biol Toxicol. 2022 Jun;38(3):487-504.
[22]PLoS Pathog. 2016 Aug 24;12(8):e1005823.
[23]Free Radic Biol Med. 2021 May 27;S0891-5849(21)00323-3.
[24]Free Radic Biol Med. 2017 Nov;112:336-349.
[25]Pharmacol Res. 2021 Jun 6;170:105712.
[26]Pharmacol Res. 2018 Nov 22;139:273-285.
[27]J Neuroinflammation. 2022 Apr 12;19(1):87.
[28]Cell Prolif. 2021 May 4;e13048.
[29]Transl Res. 2018 Apr;194:68-78.
[30]Int J Nanomedicine. 2021 Sep 29;16:6661-6679.
[31]Oxid Med Cell Longev. 2020 Jul 23;2020:3549704.
[32]Cell Biosci. 2021 Jan 7;11(1):9.
[33]Environ Microbiol. 2020 May 19.
[34]Aging Cell. 2021 Jan 2;13(1):1458-1472.
[35]Aging (Albany NY). 2020 Jun 10;12(11):11139-11151.
[36]Genes Dis. 10 September 2022.
[37]Exp Neurol. 2017 Sep;295:116-124.
[38]Int J Mol Sci. 2022 Apr 28;23(9):4907.
[39]Mol Neurobiol. 2022 Jun;59(6):3933-3946.
[40]J Cell Mol Med. 2023 Jan 9.
[41]J Cell Mol Med. 2021 Dec 28.
[42]iScience. 11 June 2022, 104582.
[43]J Mol Med. 2021 Jan 6.
[44]ESC Heart Fail. 2022 Oct 17.
[45]Front Pharmacol. 2021 Mar 9;12:616803.
[46]Front Pharmacol. 2019 Sep 3;10:968.
[47]Cancer Cell Int. 2019 Dec 10;19:332.
[48]Food Funct. 01 Jun 2022.
[49]J Anim Sci Biotechnol. 2020 Aug 5;11:77.
[50]Commun Biol. 2022 Jun 22;5(1):616.
[51]Cell Death Discov. 2022 Feb 17;8(1):69.
[52]Toxicology. 2022 Oct 6;153348.
[53]Toxicology. 2021 Dec 21;153082.
[54]J Neurochem. 2022 Oct 21.
[55]Cell Signal. 2022 Oct 18;110500.
[56]Atherosclerosis. 16 February 2022.
[57]Viruses. 2020 Mar 6;12(3):289.
[58]Int J Biochem Cell Biol. 2021, 106003.
[59]World J Gastroenterol. 2020 Apr 21;26(15):1758-1774.
[60]Life Sci. 2020 Sep 15;257:118116.
[61]Eur J Pharm Sci. 2018 May 31;121:243-250.
[62]Toxicol Res (Camb). 23 May 2022.
[63]Oncol Rep. 2020 Mar;43(3):1010-1018.
[64]Arch Biochem Biophys. 2022 Mar 30;718:109147.
[65]Arch Biochem Biophys. 2020 May 30;685:108284.
[66]Arch Biochem Biophys. 2019 Aug 15;671:42-51.
[67]Toxicol Appl Pharmacol. 2020 Feb 1;388:114874.
[68]Ann Transl Med. 2022 Feb;10(4):212.
[69]Eur J Pharmacol. 2023 Jan 20;942:175531.
[70]IUBMB Life. 2022 Jun;74(6):519-531.
[71]Reprod Toxicol. 2022 Aug 8;S0890-6238(22)00119-8.
[72]Neurochem Res. 2021 Jan 6.
[73]Exp Eye Res. 2022 Apr 28;220:109095.
[74]Behav Brain Res. 2022 Dec 16;440:114264.
[75]Toxicol In Vitro. 2023 Jan 5;105552.
[76]Brain Res. 2019 May 15;1711:68-76.
[77]Neurosci Lett. 2021 May 19;135967.
[78]Steroids. 2020 Nov;163:108699.
[79]Drug Dev Res. 2019 Jun;80(4):481-489.
[80]Exp Ther Med. 2019 Mar;17(3):2349-2358.
[81]Research Square Print. January 4th, 2023.
[82]Research Square Print. 2022 May.
[83]bioRxiv. July 28, 2021.
[84]Research Square Preprint. 2021 Oct.
[85]Research Square Preprint. 2020 Aug.

Summary

Mdivi-1 is a selective dynamin-related protein 1 ( Drp1 ) inhibitor. Mdivi-1 is a mitochondrial division/ mitophagy inhibitor.

In Vitro

Mdivi-1 inhibits Dnm1 GTPase activity in a dose-dependent manner, with an estimated EC ₅₀ of 1-10 μM. Mdivi-1 increases the apparent K _0.5 for GTP, lowers the apparent V _max for GTP hydrolysis, and causes an increase in the Hill coefficient observed for GTP in the Dnm1 GTP hydrolysis reaction ^[1] . Cells treated with mdivi-1 display decreased cytochrome c release and a reduced rate of phosphatidylserine exposure on their surface following apoptosis induction, consistent with an inhibition of apoptosis and with previous studies using other strategies to compromise DRP1 activity ^[2] . Mdivi-1 results in apoptotic cell death in ischemic retina ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The mitochondrial division DRP, Dnm1, is the target of mdivi-1 in vivo. Mdivi-1 quantitatively blocks GMPPCP- dependent Dnm1 self-assembly in a concentration range similar to its effects on mitochondrial division in vivo ^[1] . Mdivi-1 (50 mg/kg, i.p.) significantly decreases GFAP protein expression in the normal mouse retina ^[3] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 160 mg/mL ( 452.98 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8311 mL	14.1555 mL	28.3110 mL
5 mM	0.5662 mL	2.8311 mL	5.6622 mL
10 mM	0.2831 mL	1.4155 mL	2.8311 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 17% Polyethylene glycol 12-hydroxystearate in saline

Solubility: 10 mg/mL (28.31 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
4.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 4 mg/mL (11.32 mM); Clear solution
5.

Add each solvent one by one: 0.5% CMC-Na /saline water

Solubility: 2.5 mg/mL (7.08 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14(2):193-204.
[2] Tanaka A, et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29(4):409-10.
[3] Park SW, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52(5):2837-43.

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