[CAS NO. 34140-59-5] Trimebutinemaleate

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PRODUCTS SPECIFICATIONS [34140-59-5]

Catalog

HY-B0380A

Brand

MCE

CAS

34140-59-5

DESCRIPTION [34140-59-5]

Overview

MDL	MFCD00133874
Molecular Weight	503.54
Molecular Formula	C26H33NO9
SMILES	O=C(O)/C=C\C(O)=O.O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2

For research use only. We do not sell to patients.

Summary

Trimebutine maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT04403087	Chuncheon Sacred Heart Hospital	Helicobacter Pylori Infection	May 1, 2021	Phase 4
NCT03359499	Hospital Britanico	Irritable Bowel Syndrome	August 12, 2017	Phase 2\|Phase 3
NCT01984931	CM Chungmu Hospital\|Korea United Pharm. Inc.	Nausea\|Vomiting	October 2013	Phase 3
NCT02986685	Xijing Hospital of Digestive Diseases\|Ankang City Central Hospital\|Shaanxi Provincial People´s Hospital\|Baoji Central Hospital\|Hanzhong Central Hospital	Refractory Reflux Esophagitis	November 2016	Phase 4
NCT03036111	Mansoura University	Hemorrhoids	February 1, 2017	Not Applicable

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 198.59 mM ; Need ultrasonic)

H ₂ O : 25 mg/mL ( 49.65 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9859 mL	9.9297 mL	19.8594 mL
5 mM	0.3972 mL	1.9859 mL	3.9719 mL
10 mM	0.1986 mL	0.9930 mL	1.9859 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (4.96 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (2Z)-2-butenedioate (1:1)

Benzoic acid, 3,4,5-trimethoxy-, β-(dimethylamino)-β-ethylphenethyl ester maleate (1:1)

Benzoic acid, 3,4,5-trimethoxy-, 2-(dimethylamino)-2-phenylbutyl ester, (Z)-2-butenedioate (1:1)

Trimebutine maleate

Debridat

Dromostat

TM 906

Spabucol

Cerekinon

Polibutin

Digerent

Foldox

Trimedat

Gast-Reg