[CAS NO. 34175-96-7] Pterosin B

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PRODUCTS SPECIFICATIONS [34175-96-7]

Catalog

HY-N1570

Brand

MCE

CAS

34175-96-7

DESCRIPTION [34175-96-7]

Overview

MDL	MFCD01719784
Molecular Weight	218.29
Molecular Formula	C14H18O2
SMILES	O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2

For research use only. We do not sell to patients.

Summary

Pterosin B, a indanone found in bracken fern ( Pteridium aquilinum ), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 ^[1] ^[2] .

IC50 & Target

SIK3

Appearance

Solid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 1145.27 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5811 mL	22.9053 mL	45.8106 mL
5 mM	0.9162 mL	4.5811 mL	9.1621 mL
10 mM	0.4581 mL	2.2905 mL	4.5811 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.75 mg/mL (12.60 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.75 mg/mL (12.60 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.75 mg/mL (12.60 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (2R)-

1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-

1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-, (R)-

(2R)-2,3-Dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl-1H-inden-1-one

BI 2

Pterosin B

(2R)-Pterosin B

(2R)-6-(2-Hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one