[CAS NO. 342577-38-2] Velneperit

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PRODUCTS SPECIFICATIONS [342577-38-2]

Catalog

HY-14423

Brand

MCE

CAS

342577-38-2

DESCRIPTION [342577-38-2]

Overview

MDL	MFCD11973642
Molecular Weight	407.45
Molecular Formula	C17H24F3N3O3S
SMILES	FC(F)(F)C1=CN=C(NC([C@H]2CC[C@H](NS(=O)(C(C)(C)C)=O)CC2)=O)C=C1

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Transl Psychiatry. 2018 Aug 22;8(1):164.

Summary

Velneperit (S-2367) is a novel neuropeptide Y (NPY) Y5 receptor antagonist. Target: neuropeptide Y receptor Velneperit (S-2367) is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT00748605	Shionogi\|Shionogi Inc.	Obesity	June 2007	Phase 2
NCT00788528	Shionogi\|Shionogi Inc.	Obesity	August 2008	Phase 2
NCT00747929	Shionogi\|Shionogi Inc.	Obesity	June 2007	Phase 2
NCT01126970	Shionogi\|Shionogi Inc.	Obesity	April 2010	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 30 mg/mL ( 73.63 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4543 mL	12.2714 mL	24.5429 mL
5 mM	0.4909 mL	2.4543 mL	4.9086 mL
10 mM	0.2454 mL	1.2271 mL	2.4543 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Shinichi Oda*, et al. Development of an Optimized Synthetic and Purification Process of S-2367 (Velneperit), a Novel Neuropeptide Y (NPY) Y5 Receptor Antagonist. Org. Process Res. Dev., 2015, 19 (4), pp 531-536.

Synonyms

Cyclohexanecarboxamide, 4-[[(1,1-dimethylethyl)sulfonyl]amino]-N-[5-(trifluoromethyl)-2-pyridinyl]-, trans-

trans-4-[[(1,1-Dimethylethyl)sulfonyl]amino]-N-[5-(trifluoromethyl)-2-pyridinyl]cyclohexanecarboxamide

S 2367

Velneperit

N-[5-(Trifluoromethyl)pyridin-2-yl]-trans-4-(tert-butylsulfonylamino)cyclohexane-1-carboxamide