[CAS NO. 34320-83-7] TCS PrP Inhibitor 13
PRODUCTS SPECIFICATIONS [34320-83-7]
DESCRIPTION [34320-83-7]
Overview
| MDL | MFCD00506084 |
|---|---|
| Molecular Weight | 281.27 |
| Molecular Formula | C15H11N3O3 |
| SMILES | O=C1CC(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3 |
Summary
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein ( PrP C ) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC 50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis [1] .
IC50 & Target
IC50: 3 nM (PrP C in ScN2a and F3 cells) [1]
In Vitro
TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrP C and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 355.53 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5553 mL | 17.7765 mL | 35.5530 mL |
| 5 mM | 0.7111 mL | 3.5553 mL | 7.1106 mL |
| 10 mM | 0.3555 mL | 1.7777 mL | 3.5553 mL |
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1.
References
- [1] Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5
- [2] Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.