[CAS NO. 34450-16-3] N1-Acetylspermidinehydrochloride
PRODUCTS SPECIFICATIONS [34450-16-3]
DESCRIPTION [34450-16-3]
Overview
| MDL | MFCD00058261 |
|---|---|
| Molecular Weight | 260.20 |
| Molecular Formula | C9H23Cl2N3O |
| SMILES | CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl |
Summary
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA [1] [2] [3] .
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 25 mg/mL ( 96.08 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.8432 mL | 19.2160 mL | 38.4320 mL |
| 5 mM | 0.7686 mL | 3.8432 mL | 7.6864 mL |
| 10 mM | 0.3843 mL | 1.9216 mL | 3.8432 mL |
References
- [1] Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84.
- [2] Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7.
- [3] Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA.
Synonyms