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[CAS NO. 36341-25-0] YL-109
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-18619 |
| Brand: | MCE |
| CAS: | 36341-25-0 |
Overview
| MDL | MFCD00030231 |
|---|---|
| Molecular Weight | 257.31 |
| Molecular Formula | C14H11NO2S |
| SMILES | OC1=CC=C(C2=NC3=CC=CC=C3S2)C=C1OC |
Summary
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. YL-109 has ability to inhibit breast cancer cell growth and invasiveness [1] .
In Vitro
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells
[1]
.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | MCF-7 and MDA-MB-231 cells |
| Concentration: | 0.001, 0.01, 0.1, 1, 10 μM |
| Incubation Time: | 96 hours |
| Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). |
In Vivo
YL-109 (15 mg/kg; s.c. for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells [1] |
| Dosage: | 15 mg/kg |
| Administration: | S.c. every 2 days for 63 days |
| Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 388.64 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.8864 mL | 19.4318 mL | 38.8636 mL |
| 5 mM | 0.7773 mL | 3.8864 mL | 7.7727 mL |
| 10 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL |
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