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[CAS NO. 370-86-5] FCCP
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-100410 |
| Brand: | MCE |
| CAS: | 370-86-5 |
Overview
| MDL | MFCD00009699 |
|---|---|
| Molecular Weight | 254.17 |
| Molecular Formula | C10H5F3N4O |
| SMILES | N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1 |
26 Publications Citing Use of MCE
- [1]Cell Metab. 2022 Aug 11;S1550-4131(22)00310-2.
- [2]Cell Stem Cell. 2021 Sep 14;S1934-5909(21)00343-X.
- [3]Natl Sci Rev. 2021 Feb 10;8(7):nwab024.
- [4]Nat Commun. 2022 Jun 17;13(1):3486.
- [5]Nat Commun. 2022 May 13;13(1):2673.
- [6]Basic Res Cardiol. 2021 Dec 16;116(1):65.
- [7]Redox Biol. 2022 Sep 24;57:102492.
- [8]Redox Biol. 2021 Jul;43:101994.
- [9]Redox Biol. 2020 Nov 1;38:101771.
- [10]Cancer Immunol Res. 2023 Jan 23;CIR-22-0531.
- [11]Cell Rep. 2023 Jan 31;42(1):112011.
- [12]Carbohydr Polym. 8 July 2022, 119841.
- [13]Elife. 2021 May 4;10:e64480.
- [14]PLoS Biol. 2021 Apr 27;19(4):e3001197.
- [15]Cell Death Dis. 2021 Sep 6;12(9):837.
- [16]Oxid Med Cell Longev. 2022 Apr 5;2022:8192552.
- [17]Oxid Med Cell Longev. 2022 Mar 18;2022:2513837.
- [18]FASEB J. 2021 Feb;35(2):e21316.
- [19]Biochem Pharmacol. 2022 Feb 19;198:114948.
- [20]Biomed Pharmacother. June 2022, 113067.
- [21]Cancer Gene Ther. 2021 May 27.
- [22]Biomed Opt Express. 4363-4379 (2021).
- [23]Nat Cancer. 2022 Aug;3(8):945-960.
- [24]Nature Cardiovascular Research. 2022 Jul;1(7):649-664.
- [25]Life Metabolism. 24 June 2022.
- [26]Patent. US20220016148A1.
Summary
FCCP is an uncoupler of oxidative phosphorylation ( OXPHOS ) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation [1] .
In Vitro
FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability in K695sw cells. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells [1] . FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 100 mg/mL ( 393.44 mM )
Ethanol : ≥ 33.3 mg/mL ( 131.01 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9344 mL | 19.6719 mL | 39.3437 mL |
| 5 mM | 0.7869 mL | 3.9344 mL | 7.8687 mL |
| 10 mM | 0.3934 mL | 1.9672 mL | 3.9344 mL |
References
- [1] Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65.
- [2] Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33
- [3] Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080.
Synonyms
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